Reducing brain Aβ burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice

• Published in: Biomedicine & pharmacotherapy Vol. 173; p. 116404
• Main Authors: Tsay, Huey-Jen, Gan, Yu-Ling, Su, Yu-Han, Sun, Yu-Yo, Yao, Heng-Hsiang, Chen, Hui-Wen, Hsu, Ying-Ting, Hsu, John Tsu-An, Wang, Horng-Dar, Shie, Feng-Shiun
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.04.2024; Elsevier
• Subjects: Alzheimer’s disease; Anti-Aβ antibody; Fatty liver; High-fat diet; Microglial phagocytosis; Anti-Aβ antibody; Fatty liver; Alzheimer’s disease; Microglial phagocytosis; High-fat diet

High-fat diet (HFD)-induced fatty liver disease is a deteriorating risk factor for Alzheimer’s disease (AD). Mitigating fatty liver disease has been shown to attenuate AD-like pathology in animal models. However, it remains unclear whether enhancing Aβ clearance through immunotherapy would in turn a...