Evaluation of the Interaction-Based Hazard Index Formula Using Data on Four Trihalomethanes from U.S. EPA’s Multiple-Purpose Design Study

• Published in: Toxics (Basel) Vol. 12; no. 5; p. 305
• Main Authors: Hertzberg, Richard C., Teuschler, Linda K., McDonald, Anthony, Sey, Yusupha Mahtarr, Simmons, Jane Ellen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Alanine; Alanine transaminase; antagonism; Arsenic; binary mixture interactions; Chemicals; dose addition; Drinking water; environmental chemicals; Health risk assessment; Health risks; Investigations; Liver; Methods; Mixtures; synergy; Testing; Toxicity; Toxicity testing; Toxicology; Trihalomethanes; weight-of-evidence; United States; United States > US; binary mixture interactions; dose addition; synergy; weight-of-evidence; antagonism; mixture risk characterization; environmental chemicals; risk screening

The interaction-based hazard index (HIINT), a mixtures approach to characterizing toxicologic interactions, is demonstrated and evaluated by statistically analyzing data on four regulated trihalomethanes (THMs). These THMs were the subject of a multipurpose toxicology study specifically designed to...