Heart Failure–Specific Relationship Between Muscle Sympathetic Nerve Activity and Aortic Wave Reflection

• Published in: Journal of cardiac failure Vol. 25; no. 5; pp. 404 - 408
• Main Authors: Millar, Philip J., Notarius, Catherine F., Haruki, Nobuhiko, Floras, John S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019
• Subjects: Aorta - physiopathology; Augmentation index; Blood Pressure - physiology; Case-Control Studies; Diastole - physiology; Female; Heart Failure - physiopathology; heart failure with reduced ejection fraction; Humans; Male; Middle Aged; muscle sympathetic nerve activity; Muscle, Skeletal - innervation; Stroke Volume - physiology; Sympathetic Nervous System - physiopathology; Vascular Stiffness - physiology; wave reflection; muscle sympathetic nerve activity; Augmentation index; wave reflection; heart failure with reduced ejection fraction

Reflected arterial waves contribute to left ventricular (LV) afterload. Heart failure patients with reduced ejection fraction (HFrEF) are afterload sensitive and sympathetically activated. We tested the hypothesis that HFrEF patients exhibit a positive relationship between sympathetic vasoconstricto...