Self-Assembled Hydrophobic Honokiol Loaded MPEG-PCL Diblock Copolymer Micelles

Purpose Honokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a self-assembled monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelle to load honokiol to overcome its poor water solubili...

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Published in	Pharmaceutical research Vol. 26; no. 9; pp. 2164 - 2173
Main Authors	Gou, MaLing, Zheng, XiuLing, Men, Ke, Zhang, Juan, Wang, BiLan, Lv, Lei, Wang, XiuHong, Zhao, YinLan, Luo, Feng, Chen, LiJuan, Zhao, Xia, Wei, YuQuan, Qian, ZhiYong
Format	Journal Article
Language	English
Published	Boston Boston : Springer US 01.09.2009 Springer US Springer Springer Nature B.V
Subjects	Animals Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biotechnology Cancer Chemotherapy Chromatography, Gel Chromatography, High Pressure Liquid General pharmacology Herbal medicine Medical Law Medical sciences Micelles Microscopy, Electron, Transmission Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Polyesters - chemistry Polyethylene Glycols - chemistry Polymers Rats Rats, Sprague-Dawley Research Paper X-Ray Diffraction Micelle MPEG-PCL self-assembly nanomedicine honokiol Performance evaluation Pharmaceutical technology Diblock copolymer Technique Nanotechnology
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Abstract	Purpose Honokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a self-assembled monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelle to load honokiol to overcome its poor water solubility. Methods We synthesized MPEG-PCL diblock copolymer that could self-assemble into monodisperse micelles at the particle size of ca.18 nm in water. Honokiol was loaded into MPEG-PCL micelle by direct dissolution method assisted by ultrasound, without any surfactants, organic solvents, and vigorous stirring. Results The blank MPEG-PCL micelles (100 mg/mL) did not induce any hemolysis in vitro and showed very low toxicity ex vivo and in vivo. Honokiol could be molecularly incorporated into MPEG-PCL micelles at the drug loading of about 20% by direct dissolution method assisted by ultrasound. After loaded into MPEG-PCL micelles, honokiol maintained its molecular structure and anticancer activity in vitro. Honokiol could be sustained released from MPEG-PCL micelles in vitro. The honokiol loaded MPEG-PCL micelles could be lyophilized without any adjuvant. Conclusion The prepared honokiol formulation based on self-assembled MPEG-PCL micelle was stable, safe, effective, easy to produce and scale up, and showed potential clinical application.
AbstractList	Purpose Honokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a self-assembled monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelle to load honokiol to overcome its poor water solubility. Methods We synthesized MPEG-PCL diblock copolymer that could self-assemble into monodisperse micelles at the particle size of ca.18 nm in water. Honokiol was loaded into MPEG-PCL micelle by direct dissolution method assisted by ultrasound, without any surfactants, organic solvents, and vigorous stirring. Results The blank MPEG-PCL micelles (100 mg/mL) did not induce any hemolysis in vitro and showed very low toxicity ex vivo and in vivo . Honokiol could be molecularly incorporated into MPEG-PCL micelles at the drug loading of about 20% by direct dissolution method assisted by ultrasound. After loaded into MPEG-PCL micelles, honokiol maintained its molecular structure and anticancer activity in vitro . Honokiol could be sustained released from MPEG-PCL micelles in vitro . The honokiol loaded MPEG-PCL micelles could be lyophilized without any adjuvant. Conclusion The prepared honokiol formulation based on self-assembled MPEG-PCL micelle was stable, safe, effective, easy to produce and scale up, and showed potential clinical application. Honokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a self-assembled monomethoxy poly(ethylene glycol)-poly([epsilon]-caprolactone) (MPEG-PCL) micelle to load honokiol to overcome its poor water solubility. We synthesized MPEG-PCL diblock copolymer that could self-assemble into monodisperse micelles at the particle size of ca.18 nm in water. Honokiol was loaded into MPEG-PCL micelle by direct dissolution method assisted by ultrasound, without any surfactants, organic solvents, and vigorous stirring. The blank MPEG-PCL micelles (100 mg/mL) did not induce any hemolysis in vitro and showed very low toxicity ex vivo and in vivo. Honokiol could be molecularly incorporated into MPEG-PCL micelles at the drug loading of about 20% by direct dissolution method assisted by ultrasound. After loaded into MPEG-PCL micelles, honokiol maintained its molecular structure and anticancer activity in vitro. Honokiol could be sustained released from MPEG-PCL micelles in vitro. The honokiol loaded MPEG-PCL micelles could be lyophilized without any adjuvant. The prepared honokiol formulation based on self-assembled MPEG-PCL micelle was stable, safe, effective, easy to produce and scale up, and showed potential clinical application. [PUBLICATION ABSTRACT] Purpose Honokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a self-assembled monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelle to load honokiol to overcome its poor water solubility. Methods We synthesized MPEG-PCL diblock copolymer that could self-assemble into monodisperse micelles at the particle size of ca.18 nm in water. Honokiol was loaded into MPEG-PCL micelle by direct dissolution method assisted by ultrasound, without any surfactants, organic solvents, and vigorous stirring. Results The blank MPEG-PCL micelles (100 mg/mL) did not induce any hemolysis in vitro and showed very low toxicity ex vivo and in vivo. Honokiol could be molecularly incorporated into MPEG-PCL micelles at the drug loading of about 20% by direct dissolution method assisted by ultrasound. After loaded into MPEG-PCL micelles, honokiol maintained its molecular structure and anticancer activity in vitro. Honokiol could be sustained released from MPEG-PCL micelles in vitro. The honokiol loaded MPEG-PCL micelles could be lyophilized without any adjuvant. Conclusion The prepared honokiol formulation based on self-assembled MPEG-PCL micelle was stable, safe, effective, easy to produce and scale up, and showed potential clinical application. Honokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a self-assembled monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone) (MPEG-PCL) micelle to load honokiol to overcome its poor water solubility. We synthesized MPEG-PCL diblock copolymer that could self-assemble into monodisperse micelles at the particle size of ca.18 nm in water. Honokiol was loaded into MPEG-PCL micelle by direct dissolution method assisted by ultrasound, without any surfactants, organic solvents, and vigorous stirring. The blank MPEG-PCL micelles (100 mg/mL) did not induce any hemolysis in vitro and showed very low toxicity ex vivo and in vivo. Honokiol could be molecularly incorporated into MPEG-PCL micelles at the drug loading of about 20% by direct dissolution method assisted by ultrasound. After loaded into MPEG-PCL micelles, honokiol maintained its molecular structure and anticancer activity in vitro. Honokiol could be sustained released from MPEG-PCL micelles in vitro. The honokiol loaded MPEG-PCL micelles could be lyophilized without any adjuvant. The prepared honokiol formulation based on self-assembled MPEG-PCL micelle was stable, safe, effective, easy to produce and scale up, and showed potential clinical application. PURPOSEHonokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a self-assembled monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone) (MPEG-PCL) micelle to load honokiol to overcome its poor water solubility. METHODSWe synthesized MPEG-PCL diblock copolymer that could self-assemble into monodisperse micelles at the particle size of ca.18 nm in water. Honokiol was loaded into MPEG-PCL micelle by direct dissolution method assisted by ultrasound, without any surfactants, organic solvents, and vigorous stirring. RESULTSThe blank MPEG-PCL micelles (100 mg/mL) did not induce any hemolysis in vitro and showed very low toxicity ex vivo and in vivo. Honokiol could be molecularly incorporated into MPEG-PCL micelles at the drug loading of about 20% by direct dissolution method assisted by ultrasound. After loaded into MPEG-PCL micelles, honokiol maintained its molecular structure and anticancer activity in vitro. Honokiol could be sustained released from MPEG-PCL micelles in vitro. The honokiol loaded MPEG-PCL micelles could be lyophilized without any adjuvant. CONCLUSIONThe prepared honokiol formulation based on self-assembled MPEG-PCL micelle was stable, safe, effective, easy to produce and scale up, and showed potential clinical application.
Author	Lv, Lei Chen, LiJuan Wei, YuQuan Zhao, Xia Gou, MaLing Zhang, Juan Luo, Feng Wang, BiLan Wang, XiuHong Zhao, YinLan Qian, ZhiYong Zheng, XiuLing Men, Ke
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Cites_doi	10.1038/nbt1006-1211 10.1016/j.ijpharm.2008.10.027 10.1182/blood-2004-11-4273 10.1016/j.progpolymsci.2007.09.003 10.3322/CA.2007.0003 10.1016/j.biomaterials.2006.03.006 10.1016/j.jconrel.2005.09.034 10.1007/s00432-008-0375-5 10.1023/B:PHAM.0000033005.25698.9c 10.1016/j.febslet.2006.08.064 10.1038/nrc1566 10.1016/0006-2952(94)90187-2 10.1158/0008-5472.CAN-04-2550 10.1126/science.310.5751.1132 10.1021/bm049845j 10.1016/j.ijpharm.2008.03.023 10.1016/S0169-409X(96)00401-2 10.1016/S0142-9612(02)00248-X 10.1055/s-2003-37707 10.1016/j.chroma.2006.09.098 10.1074/jbc.M302967200 10.1002/ptr.2472 10.1007/s10856-007-3361-6 10.1080/08977190701671613 10.1016/0049-3848(88)90336-2 10.1073/pnas.0931428100 10.1002/pat.975 10.1182/blood-2005-01-0346 10.1016/j.jconrel.2004.06.003 10.1016/S0142-9612(00)00393-8 10.1093/jnci/djm027 10.1016/S0014-2999(03)02121-6 10.1186/1471-2407-8-242 10.1016/j.ijpharm.2008.08.027 10.1158/1535-7163.MCT-07-0217 10.1016/j.jconrel.2007.12.017 10.1371/journal.pone.0001096 10.1021/nl801736q 10.1002/jbm.b.30858 10.1158/1541-7786.MCR-06-0076 10.1016/j.canlet.2005.11.031 10.3748/wjg.v10.i15.2205 10.1111/j.1527-3458.2000.tb00136.x 10.1002/jbm.a.32546 10.1007/BF03218657
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References	Gou, Dai, Li, Wang, Gong, Xie (CR29) 2008; 19 Hou, Chen, Yang, Zhou, Jiang, Zhong (CR17) 2008; 22 Karnik, Gu, Basto, Cannizzaro, Dean, Kyei-Manu (CR41) 2008; 8 Zhang, Feng (CR26) 2006; 27 Chen, Zhang, Yang, Fan, Tang, Garrard (CR33) 2007; 1142 Jiang, Fan, Yang, Guo, Hou, Chen (CR16) 2008; 8 Liou, Lin, Huang, Chih, Tsai (CR4) 2003; 69 Ganta, Devalapally, Shahiwala, Amiji (CR22) 2008; 126 Lee, Kim, Moon (CR7) 2006; 580 Kim, Lee, Baik, Kang (CR27) 2003; 24 Maruyama, Kuribara (CR5) 2000; 6 Lo YC, Teng, Chen, Chen, Hong (CR3) 1994; 47 Shen, Guo, Lu (CR34) 2008; 19 Liu, Gong, Huang, Wang, Pan, Zhang (CR35) 2008; 84B Jette, Law, Schmitt, Kwon (CR36) 2004; 21 Saffie-Sieverb, Ogden, Parry-Billings (CR24) 2005; Summer CR31 Tang, Du, Wang, Liu, Hang, Liang (CR46) 2007; 99 Torchilin, Lukyanov, Gao, Sternberg (CR25) 2003; 100 Luo, Zhong, Chen, Qi, Fu, Yang (CR15) 2008; 134 Farokhzad, Jon, Khademhosseini, Tran, LaVan, Langer (CR39) 2004; 64 Wang, Yang, Chen, Shin (CR23) 2008; 58 Gou, Li, Dai, Gong, Wang, Xie (CR30) 2008; 359 Kwon, Okano (CR40) 1996; 21 Ferrari (CR20) 2005; 5 Shuai, Ai, Nasongkla, Kim, Gao (CR42) 2004; 98 Battle, Arbiser, Frank (CR9) 2005; 106 Sheu, Liu, Lan (CR10) 2007; 2 Hahm, Singh (CR6) 2007; 6 Xu, Lu, Hu (CR14) 2006; 243 Wei, Gong, Shi, Fu, Men, Zeng (CR32) 2009; 369 Kim, Lee, Shin, Kang (CR44) 2001; 22 Wagner, Dullaart, Bock, Zweck (CR18) 2004; 24 Gaucher, Dufresne, Sant, Kang, Maysinger, Leroux (CR37) 2005; 109 Ishitsuka, Hideshima, Hamasaki, Raje, Kumar, Hideshima (CR13) 2005; 106 Service (CR21) 2005; 310 Liou, Shen, Chen, Tsao, Tsai (CR2) 2003; 475 Parka, Lee, Kim, Park, Kim, Kwon (CR19) 2008; 33 Teng, Chen, Ko, Lee, Huang, Chen (CR1) 1998; 50 Gong, Shia, Dong, Kan, Gou, Wang, Li (CR45) 2009; 365 Wang, Chen, Chen, Wu, Xu, Zheng (CR11) 2004; 10 Gou, Huang, Qian, Yang, Dai, Li (CR38) 2007; 25 Ahn, Sethi, Shishodia, Sung, Arbiser, Aggarwal (CR12) 2006; 4 Lee, Hwang, Lee (CR43) 2009; 17 Bai, Cerimele, Ushio-Fukai, Waqas, Campbell, Govindarajan (CR8) 2003; 278 Hu, Zhang, Cao, Ge, Jiang, Yang (CR28) 2004; 4 17455282 - J Biomed Mater Res B Appl Biomater. 2008 Jan;84(1):165-75 18448286 - Int J Pharm. 2008 Jul 9;359(1-2):228-33 18227410 - CA Cancer J Clin. 2008 Mar-Apr;58(2):97-110 16962592 - FEBS Lett. 2006 Oct 2;580(22):5177-84 8117323 - Biochem Pharmacol. 1994 Feb 9;47(3):549-53 18197366 - J Mater Sci Mater Med. 2008 Jul;19(7):2605-8 17033654 - Nat Biotechnol. 2006 Oct;24(10):1211-7 15312997 - J Control Release. 2004 Aug 27;98 (3):415-26 15802533 - Blood. 2005 Jul 15;106(2):690-7 16289422 - J Control Release. 2005 Dec 5;109(1-3):169-88 17917912 - Growth Factors. 2007 Jun;25(3):202-208 17222860 - J Chromatogr A. 2007 Feb 23;1142(2):115-22 16293748 - Science. 2005 Nov 18;310(5751):1132-4 19028556 - Int J Pharm. 2009 Mar 18;369(1-2):170-5 17596572 - J Natl Cancer Inst. 2007 Jul 4;99(13):1004-15 15290858 - Pharm Res. 2004 Jul;21(7):1184-91 15259066 - World J Gastroenterol. 2004 Aug 1;10(15):2205-8 15520166 - Cancer Res. 2004 Nov 1;64(21):7668-72 16564085 - Biomaterials. 2006 Jul;27(21):4025-33 12816951 - J Biol Chem. 2003 Sep 12;278(37):35501-7 16966432 - Mol Cancer Res. 2006 Sep;4(9):621-33 18570244 - Phytother Res. 2008 Aug;22(8):1125-32 18350317 - J Cancer Res Clin Oncol. 2008 Sep;134(9):937-45 15360284 - Biomacromolecules. 2004 Sep-Oct;5(5):1756-62 12716967 - Proc Natl Acad Sci U S A. 2003 May 13;100(10):6039-44 12417178 - Biomaterials. 2003 Jan;24(1):55-63 15738981 - Nat Rev Cancer. 2005 Mar;5(3):161-71 11426885 - Biomaterials. 2001 Jul;22(14):2049-56 18793709 - Int J Pharm. 2009 Jan 5;365(1-2):89-99 19557789 - J Biomed Mater Res A. 2010 Apr;93(1):219-26 16406853 - Cancer Lett. 2006 Nov 18;243(2):274-80 12624817 - Planta Med. 2003 Feb;69(2):130-4 3413728 - Thromb Res. 1988 Jun 15;50(6):757-65 18656990 - Nano Lett. 2008 Sep;8(9):2906-12 12954355 - Eur J Pharmacol. 2003 Aug 15;475(1-3):19-27 18706101 - BMC Cancer. 2008 Aug 16;8:242 15870175 - Blood. 2005 Sep 1;106(5):1794-800 17971859 - PLoS One. 2007 Oct 31;2(10):e1096 17938262 - Mol Cancer Ther. 2007 Oct;6(10 ):2686-95 18261822 - J Control Release. 2008 Mar 20;126(3):187-204 KS Ahn (9929_CR12) 2006; 4 VP Torchilin (9929_CR25) 2003; 100 YC Lo YC (9929_CR3) 1994; 47 N Tang (9929_CR46) 2007; 99 KT Liou (9929_CR4) 2003; 69 RF Service (9929_CR21) 2005; 310 ML Gou (9929_CR38) 2007; 25 X Shuai (9929_CR42) 2004; 98 Z Zhang (9929_CR26) 2006; 27 CM Teng (9929_CR1) 1998; 50 X Bai (9929_CR8) 2003; 278 ER Hahm (9929_CR6) 2007; 6 D Xu (9929_CR14) 2006; 243 CY Gong (9929_CR45) 2009; 365 XW Wei (9929_CR32) 2009; 369 9929_CR31 W Hou (9929_CR17) 2008; 22 B Lee (9929_CR7) 2006; 580 G Gaucher (9929_CR37) 2005; 109 KT Liou (9929_CR2) 2003; 475 OC Farokhzad (9929_CR39) 2004; 64 Y Maruyama (9929_CR5) 2000; 6 QQ Jiang (9929_CR16) 2008; 8 S Ganta (9929_CR22) 2008; 126 M Ferrari (9929_CR20) 2005; 5 ML Sheu (9929_CR10) 2007; 2 V Wagner (9929_CR18) 2004; 24 X Wang (9929_CR23) 2008; 58 CB Liu (9929_CR35) 2008; 84B T Wang (9929_CR11) 2004; 10 K Ishitsuka (9929_CR13) 2005; 106 L Chen (9929_CR33) 2007; 1142 SY Kim (9929_CR27) 2003; 24 C Shen (9929_CR34) 2008; 19 KK Jette (9929_CR36) 2004; 21 R Karnik (9929_CR41) 2008; 8 ML Gou (9929_CR30) 2008; 359 JH Parka (9929_CR19) 2008; 33 GS Kwon (9929_CR40) 1996; 21 Y Hu (9929_CR28) 2004; 4 H Luo (9929_CR15) 2008; 134 JS Lee (9929_CR43) 2009; 17 TE Battle (9929_CR9) 2005; 106 SY Kim (9929_CR44) 2001; 22 9929_CR24 ML Gou (9929_CR29) 2008; 19
References_xml	– volume: 17 start-page: 72 year: 2009 end-page: 8 ident: CR43 article-title: Formation of poly(ethylene glycol)-Poly(ε-caprolactone) nanoparticles via nanoprecipitation publication-title: Macromol Res contributor: fullname: Lee – volume: 10 start-page: 2205 year: 2004 end-page: 8 ident: CR11 article-title: Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO publication-title: World J Gastroenterol contributor: fullname: Zheng – volume: 24 start-page: 1211 year: 2004 end-page: 7 ident: CR18 article-title: The emerging nanomedicine landscape publication-title: Nat Biotech doi: 10.1038/nbt1006-1211 contributor: fullname: Zweck – volume: 369 start-page: 170 year: 2009 end-page: 5 ident: CR32 article-title: Self-assembled honokiol-loaded micelles based on poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) copolymer publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2008.10.027 contributor: fullname: Zeng – volume: 106 start-page: 690 year: 2005 end-page: 7 ident: CR9 article-title: The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells publication-title: Blood doi: 10.1182/blood-2004-11-4273 contributor: fullname: Frank – volume: 33 start-page: 113 year: 2008 end-page: 37 ident: CR19 article-title: Polymeric nanomedicine for cancer therapy publication-title: Prog Polym Sci doi: 10.1016/j.progpolymsci.2007.09.003 contributor: fullname: Kwon – volume: 58 start-page: 97 year: 2008 end-page: 110 ident: CR23 article-title: Application of nanotechnology in cancer therapy and imaging publication-title: CA Cancer J Clin doi: 10.3322/CA.2007.0003 contributor: fullname: Shin – volume: 27 start-page: 4025 year: 2006 end-page: 33 ident: CR26 article-title: The drug encapsulation efficiency, in vitro drug release, cellular uptake and cytotoxicity of paclitaxel-loaded poly(lactide)—tocopheryl polyethylene glycol succinate nanoparticles publication-title: Biomaterials doi: 10.1016/j.biomaterials.2006.03.006 contributor: fullname: Feng – volume: 109 start-page: 169 year: 2005 end-page: 88 ident: CR37 article-title: Block copolymer micelles: preparation, characterization and application in drug delivery publication-title: J Control Rel doi: 10.1016/j.jconrel.2005.09.034 contributor: fullname: Leroux – volume: 134 start-page: 937 year: 2008 end-page: 45 ident: CR15 article-title: Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer publication-title: J Cancer Res Clin Oncology doi: 10.1007/s00432-008-0375-5 contributor: fullname: Yang – volume: 21 start-page: 1184 year: 2004 end-page: 91 ident: CR36 article-title: Preparation and drug loading of poly(Ethylene Glycol)-block-Poly(ε-Caprolactone) micelles through the evaporation of a cosolvent azeotrope publication-title: Pharm Res doi: 10.1023/B:PHAM.0000033005.25698.9c contributor: fullname: Kwon – volume: 580 start-page: 5177 year: 2006 end-page: 84 ident: CR7 article-title: Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells publication-title: FEBS Lett doi: 10.1016/j.febslet.2006.08.064 contributor: fullname: Moon – volume: 5 start-page: 167 year: 2005 end-page: 71 ident: CR20 article-title: Cancer nanotechnology: opportunities and challenges publication-title: Nat Rev Cancer doi: 10.1038/nrc1566 contributor: fullname: Ferrari – volume: 47 start-page: 549 year: 1994 end-page: 53 ident: CR3 article-title: Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(94)90187-2 contributor: fullname: Hong – volume: 64 start-page: 7668 year: 2004 end-page: 72 ident: CR39 article-title: Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-2550 contributor: fullname: Langer – volume: 310 start-page: 1132 year: 2005 end-page: 4 ident: CR21 article-title: Nanotechnology takes aim at cancer publication-title: Science doi: 10.1126/science.310.5751.1132 contributor: fullname: Service – volume: Summer start-page: 71 year: 2005 ident: CR24 article-title: Nanotechnology approaches to solving the problems of poorly water-soluble drugs publication-title: Drug Discovery World contributor: fullname: Parry-Billings – volume: 4 start-page: 1756 year: 2004 end-page: 62 ident: CR28 article-title: Degradation behavior of poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone) micelles in aqueous solution publication-title: Biomacromolecules doi: 10.1021/bm049845j contributor: fullname: Yang – volume: 359 start-page: 228 year: 2008 end-page: 33 ident: CR30 article-title: A novel injectable local hydrophobic drug delivery system: biodegradable nanoparticles in thermo-sensitive hydrogel publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2008.03.023 contributor: fullname: Xie – volume: 21 start-page: 107 year: 1996 end-page: 16 ident: CR40 article-title: Polymeric micelles as new drug carriers publication-title: Advan Drug Deliver Rev doi: 10.1016/S0169-409X(96)00401-2 contributor: fullname: Okano – volume: 24 start-page: 55 year: 2003 end-page: 63 ident: CR27 article-title: Toxic characteristics of methoxy poly(ethylene glycol)/poly(ε-caprolactone) nanospheres; in vitro and in vivo studies in the normal mice publication-title: Biomaterials doi: 10.1016/S0142-9612(02)00248-X contributor: fullname: Kang – volume: 69 start-page: 130 year: 2003 end-page: 4 ident: CR4 article-title: Honokiol ameliorates cerebral infarction from ischemia-reperfusion injury in rats publication-title: Planta Med doi: 10.1055/s-2003-37707 contributor: fullname: Tsai – volume: 1142 start-page: 115 year: 2007 end-page: 22 ident: CR33 article-title: Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography publication-title: J Chromatogr A doi: 10.1016/j.chroma.2006.09.098 contributor: fullname: Garrard – volume: 278 start-page: 35501 year: 2003 end-page: 7 ident: CR8 article-title: Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo publication-title: J Biol Chem doi: 10.1074/jbc.M302967200 contributor: fullname: Govindarajan – volume: 22 start-page: 1125 year: 2008 end-page: 32 ident: CR17 article-title: Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models publication-title: Phytother Res doi: 10.1002/ptr.2472 contributor: fullname: Zhong – volume: 19 start-page: 2605 year: 2008 end-page: 8 ident: CR29 article-title: Preparation and characterization of honokiol nanoparticles publication-title: J Mater Sci: Mater Med doi: 10.1007/s10856-007-3361-6 contributor: fullname: Xie – volume: 25 start-page: 202 year: 2007 end-page: 8 ident: CR38 article-title: Preparation of anionic poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) copolymeric nanoparticles as basic protein antigen carrier publication-title: Growth Factors doi: 10.1080/08977190701671613 contributor: fullname: Li – volume: 50 start-page: 757 year: 1998 end-page: 65 ident: CR1 article-title: Two antiplatelet agents from Magnolia officinalis publication-title: Thromb Res doi: 10.1016/0049-3848(88)90336-2 contributor: fullname: Chen – volume: 6 start-page: 35 year: 2000 end-page: 44 ident: CR5 article-title: Overview of the pharmacological features of honokiol publication-title: CNS Drug Rev contributor: fullname: Kuribara – volume: 100 start-page: 6039 year: 2003 end-page: 44 ident: CR25 article-title: Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs publication-title: Proc Nat Acad Sci USA doi: 10.1073/pnas.0931428100 contributor: fullname: Sternberg – volume: 19 start-page: 66 year: 2008 end-page: 72 ident: CR34 article-title: Degradation behaviors of monomethoxy poly(ethylene glycol)-b-poly(e-caprolactone) nanoparticles in aqueous solution publication-title: Polym Adv Technol doi: 10.1002/pat.975 contributor: fullname: Lu – volume: 106 start-page: 1794 year: 2005 end-page: 800 ident: CR13 article-title: Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis publication-title: Blood doi: 10.1182/blood-2005-01-0346 contributor: fullname: Hideshima – volume: 98 start-page: 415 year: 2004 end-page: 26 ident: CR42 article-title: Micellar carriers based on block copolymers of poly(q-caprolactone) and poly(ethylene glycol) for doxorubicin delivery publication-title: J Control Rel doi: 10.1016/j.jconrel.2004.06.003 contributor: fullname: Gao – volume: 22 start-page: 2049 year: 2001 end-page: 56 ident: CR44 article-title: Indomethacin-loaded methoxy poly(ethylene glycol)/poly(ε-caprolactone) diblock copolymeric nanosphere: pharmacokinetic characteristics of indomethacin in the normal Sprague-Dawley rats publication-title: Biomaterials doi: 10.1016/S0142-9612(00)00393-8 contributor: fullname: Kang – volume: 99 start-page: 1004 year: 2007 end-page: 15 ident: CR46 article-title: Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djm027 contributor: fullname: Liang – volume: 475 start-page: 19 year: 2003 end-page: 27 ident: CR2 article-title: The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production publication-title: Eur J Pharmacol doi: 10.1016/S0014-2999(03)02121-6 contributor: fullname: Tsai – volume: 8 start-page: 242 year: 2008 end-page: 9 ident: CR16 article-title: Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model publication-title: BMC Cancer doi: 10.1186/1471-2407-8-242 contributor: fullname: Chen – ident: CR31 – volume: 365 start-page: 89 year: 2009 end-page: 99 ident: CR45 article-title: Synthesis, characterization, degradation , and in vitro drug release behavior of thermosensitive hydrogel based on PEG-PCL-PEG block copolymers publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2008.08.027 contributor: fullname: Li – volume: 6 start-page: 2686 year: 2007 end-page: 95 ident: CR6 article-title: Honokiol causes G0–G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-07-0217 contributor: fullname: Singh – volume: 126 start-page: 187 year: 2008 end-page: 204 ident: CR22 article-title: A review of stimuli-responsive nanocarriers for drug and gene delivery publication-title: J Control Rel doi: 10.1016/j.jconrel.2007.12.017 contributor: fullname: Amiji – volume: 2 start-page: e1096 year: 2007 ident: CR10 article-title: Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth publication-title: PLoS ONE doi: 10.1371/journal.pone.0001096 contributor: fullname: Lan – volume: 8 start-page: 2906 year: 2008 end-page: 12 ident: CR41 article-title: Microfluidic platform for controlled synthesis of polymeric nanoparticles publication-title: Nano Lett doi: 10.1021/nl801736q contributor: fullname: Kyei-Manu – volume: 84B start-page: 165 year: 2008 end-page: 75 ident: CR35 article-title: Thermoreversible Gel–Sol behavior of biodegradable PCL-PEG-PCL triblock copolymer in aqueous solutions publication-title: J Biomed Mater Res Part B: Appl Biomater doi: 10.1002/jbm.b.30858 contributor: fullname: Zhang – volume: 4 start-page: 621 year: 2006 end-page: 33 ident: CR12 article-title: Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-KB activation pathway publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-06-0076 contributor: fullname: Aggarwal – volume: 243 start-page: 274 year: 2006 end-page: 80 ident: CR14 article-title: Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol publication-title: Cancer Lett doi: 10.1016/j.canlet.2005.11.031 contributor: fullname: Hu – volume: 69 start-page: 130 year: 2003 ident: 9929_CR4 publication-title: Planta Med doi: 10.1055/s-2003-37707 contributor: fullname: KT Liou – volume: 243 start-page: 274 year: 2006 ident: 9929_CR14 publication-title: Cancer Lett doi: 10.1016/j.canlet.2005.11.031 contributor: fullname: D Xu – volume: 99 start-page: 1004 year: 2007 ident: 9929_CR46 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djm027 contributor: fullname: N Tang – volume: 25 start-page: 202 year: 2007 ident: 9929_CR38 publication-title: Growth Factors doi: 10.1080/08977190701671613 contributor: fullname: ML Gou – volume: 50 start-page: 757 year: 1998 ident: 9929_CR1 publication-title: Thromb Res doi: 10.1016/0049-3848(88)90336-2 contributor: fullname: CM Teng – volume: 27 start-page: 4025 year: 2006 ident: 9929_CR26 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2006.03.006 contributor: fullname: Z Zhang – volume: 4 start-page: 621 year: 2006 ident: 9929_CR12 publication-title: Mol Cancer Res doi: 10.1158/1541-7786.MCR-06-0076 contributor: fullname: KS Ahn – volume: 24 start-page: 55 year: 2003 ident: 9929_CR27 publication-title: Biomaterials doi: 10.1016/S0142-9612(02)00248-X contributor: fullname: SY Kim – volume: 134 start-page: 937 year: 2008 ident: 9929_CR15 publication-title: J Cancer Res Clin Oncology doi: 10.1007/s00432-008-0375-5 contributor: fullname: H Luo – volume: 64 start-page: 7668 year: 2004 ident: 9929_CR39 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-2550 contributor: fullname: OC Farokhzad – volume: 22 start-page: 2049 year: 2001 ident: 9929_CR44 publication-title: Biomaterials doi: 10.1016/S0142-9612(00)00393-8 contributor: fullname: SY Kim – volume: 359 start-page: 228 year: 2008 ident: 9929_CR30 publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2008.03.023 contributor: fullname: ML Gou – volume: 10 start-page: 2205 year: 2004 ident: 9929_CR11 publication-title: World J Gastroenterol doi: 10.3748/wjg.v10.i15.2205 contributor: fullname: T Wang – volume: 8 start-page: 242 year: 2008 ident: 9929_CR16 publication-title: BMC Cancer doi: 10.1186/1471-2407-8-242 contributor: fullname: QQ Jiang – volume: 4 start-page: 1756 year: 2004 ident: 9929_CR28 publication-title: Biomacromolecules doi: 10.1021/bm049845j contributor: fullname: Y Hu – volume: 19 start-page: 2605 year: 2008 ident: 9929_CR29 publication-title: J Mater Sci: Mater Med contributor: fullname: ML Gou – volume: 126 start-page: 187 year: 2008 ident: 9929_CR22 publication-title: J Control Rel doi: 10.1016/j.jconrel.2007.12.017 contributor: fullname: S Ganta – volume: 47 start-page: 549 year: 1994 ident: 9929_CR3 publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(94)90187-2 contributor: fullname: YC Lo YC – volume: 98 start-page: 415 year: 2004 ident: 9929_CR42 publication-title: J Control Rel doi: 10.1016/j.jconrel.2004.06.003 contributor: fullname: X Shuai – volume: 1142 start-page: 115 year: 2007 ident: 9929_CR33 publication-title: J Chromatogr A doi: 10.1016/j.chroma.2006.09.098 contributor: fullname: L Chen – volume: 100 start-page: 6039 year: 2003 ident: 9929_CR25 publication-title: Proc Nat Acad Sci USA doi: 10.1073/pnas.0931428100 contributor: fullname: VP Torchilin – volume: 106 start-page: 1794 year: 2005 ident: 9929_CR13 publication-title: Blood doi: 10.1182/blood-2005-01-0346 contributor: fullname: K Ishitsuka – volume: 109 start-page: 169 year: 2005 ident: 9929_CR37 publication-title: J Control Rel doi: 10.1016/j.jconrel.2005.09.034 contributor: fullname: G Gaucher – volume: 21 start-page: 107 year: 1996 ident: 9929_CR40 publication-title: Advan Drug Deliver Rev doi: 10.1016/S0169-409X(96)00401-2 contributor: fullname: GS Kwon – volume: 5 start-page: 167 year: 2005 ident: 9929_CR20 publication-title: Nat Rev Cancer contributor: fullname: M Ferrari – ident: 9929_CR24 – volume: 21 start-page: 1184 year: 2004 ident: 9929_CR36 publication-title: Pharm Res doi: 10.1023/B:PHAM.0000033005.25698.9c contributor: fullname: KK Jette – volume: 365 start-page: 89 year: 2009 ident: 9929_CR45 publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2008.08.027 contributor: fullname: CY Gong – volume: 106 start-page: 690 year: 2005 ident: 9929_CR9 publication-title: Blood doi: 10.1182/blood-2004-11-4273 contributor: fullname: TE Battle – volume: 475 start-page: 19 year: 2003 ident: 9929_CR2 publication-title: Eur J Pharmacol doi: 10.1016/S0014-2999(03)02121-6 contributor: fullname: KT Liou – volume: 33 start-page: 113 year: 2008 ident: 9929_CR19 publication-title: Prog Polym Sci doi: 10.1016/j.progpolymsci.2007.09.003 contributor: fullname: JH Parka – volume: 22 start-page: 1125 year: 2008 ident: 9929_CR17 publication-title: Phytother Res doi: 10.1002/ptr.2472 contributor: fullname: W Hou – volume: 8 start-page: 2906 year: 2008 ident: 9929_CR41 publication-title: Nano Lett doi: 10.1021/nl801736q contributor: fullname: R Karnik – volume: 278 start-page: 35501 year: 2003 ident: 9929_CR8 publication-title: J Biol Chem doi: 10.1074/jbc.M302967200 contributor: fullname: X Bai – volume: 310 start-page: 1132 year: 2005 ident: 9929_CR21 publication-title: Science doi: 10.1126/science.310.5751.1132 contributor: fullname: RF Service – volume: 6 start-page: 35 year: 2000 ident: 9929_CR5 publication-title: CNS Drug Rev doi: 10.1111/j.1527-3458.2000.tb00136.x contributor: fullname: Y Maruyama – volume: 84B start-page: 165 year: 2008 ident: 9929_CR35 publication-title: J Biomed Mater Res Part B: Appl Biomater doi: 10.1002/jbm.b.30858 contributor: fullname: CB Liu – ident: 9929_CR31 doi: 10.1002/jbm.a.32546 – volume: 369 start-page: 170 year: 2009 ident: 9929_CR32 publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2008.10.027 contributor: fullname: XW Wei – volume: 580 start-page: 5177 year: 2006 ident: 9929_CR7 publication-title: FEBS Lett doi: 10.1016/j.febslet.2006.08.064 contributor: fullname: B Lee – volume: 24 start-page: 1211 year: 2004 ident: 9929_CR18 publication-title: Nat Biotech doi: 10.1038/nbt1006-1211 contributor: fullname: V Wagner – volume: 17 start-page: 72 year: 2009 ident: 9929_CR43 publication-title: Macromol Res doi: 10.1007/BF03218657 contributor: fullname: JS Lee – volume: 58 start-page: 97 year: 2008 ident: 9929_CR23 publication-title: CA Cancer J Clin doi: 10.3322/CA.2007.0003 contributor: fullname: X Wang – volume: 19 start-page: 66 year: 2008 ident: 9929_CR34 publication-title: Polym Adv Technol doi: 10.1002/pat.975 contributor: fullname: C Shen – volume: 6 start-page: 2686 year: 2007 ident: 9929_CR6 publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-07-0217 contributor: fullname: ER Hahm – volume: 2 start-page: e1096 year: 2007 ident: 9929_CR10 publication-title: PLoS ONE doi: 10.1371/journal.pone.0001096 contributor: fullname: ML Sheu
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Snippet	Purpose Honokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a... Purpose Honokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a... Honokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a... PURPOSEHonokiol showed potential application in cancer treatment, but its poor water solubility restricts its clinical application greatly. So, we designed a...
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SubjectTerms	Animals Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biotechnology Cancer Chemotherapy Chromatography, Gel Chromatography, High Pressure Liquid General pharmacology Herbal medicine Medical Law Medical sciences Micelles Microscopy, Electron, Transmission Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Polyesters - chemistry Polyethylene Glycols - chemistry Polymers Rats Rats, Sprague-Dawley Research Paper X-Ray Diffraction
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Title	Self-Assembled Hydrophobic Honokiol Loaded MPEG-PCL Diblock Copolymer Micelles
URI	https://link.springer.com/article/10.1007/s11095-009-9929-8 https://www.ncbi.nlm.nih.gov/pubmed/19568695 https://www.proquest.com/docview/222683993/abstract/ https://search.proquest.com/docview/67548208
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