Evaluation of a novel inactivated vaccine against duck circovirus in muscovy ducks

• Published in: Veterinary microbiology Vol. 241; p. 108574
• Main Authors: Zhaolong, Li, Guanghua, Fu, Zhihua, Feng, Jianhua, Chen, Shaohua, Shi, Rongchang, Liu, Longfei, Cheng, Hongmei, Chen, Chunhe, Wan, Yu, Huang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2020; Elsevier BV
• Subjects: Apoptosis; bird diseases; breeding; Bursa of Fabricius; Cairina moschata; Cell culture; Circovirus; ducks; DuCV; Immune response; immunosuppression; Inactivated vaccine; inactivated vaccines; industry; Inoculation; Leukocytes (mononuclear); Lymphocytes; mononuclear leukocytes; Muscovy ducks; neutralizing antibodies; pathogens; Peripheral blood mononuclear cells; Spleen; thymus gland; Vaccines; viral shedding; viral vaccines; Waterfowl; Peripheral blood mononuclear cells; DuCV; Muscovy ducks; Inactivated vaccine

•An inactivated DuCV vaccine was developed using PBMC culture medium in vitro.•The inactivated DuCV vaccine induced efficient systemic immune responses.•This DuCV vaccine enhanced protective immune responses against DuCV infection. Duck circovirus (DuCV), an immunosuppressive pathogen, causes seriou...