Screening for SNPs and Haplotypes in the CYP3A7 Gene in Chinese Populations

• Published in: Pharmacogenomics Vol. 8; no. 6; pp. 559 - 566
• Main Authors: Du, Jing, Shi, Yongyong, Zhang, Aiping, Wang, Lei, Xuan, Jiekun, He, Guang, Xu, Lingyun, Xu, Mingsheng, Shu, Anli, Yu, Lan, Li, Xingwang, Meng, Junwei, Feng, Guoyin, Xing, Qinghe, He, Lin
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.06.2007
• Subjects: Adult; Aryl Hydrocarbon Hydroxylases - analysis; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Asian Continental Ancestry Group - genetics; Cancer; Care and treatment; Cytochrome P-450; Cytochrome P-450 CYP3A; Female; Gene Frequency - genetics; Genetic aspects; Genetic Testing - methods; Haplotypes - genetics; Humans; Male; Middle Aged; Polymorphism, Genetic - genetics; Polymorphism, Single Nucleotide - genetics; Substrate Specificity - genetics

To determine the frequencies and haplotypes of the cytochrome P450 (CYP)3A7 gene in three Chinese ethnic groups, namely, Han, She and Dong. SNP analyses of the CYP3A7 gene were carried out on three groups of healthy Chinese subjects consisting of 539 Han, 264 She and 273 Dong subjects, using direct...