Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo

• Published in: Cancer letters Vol. 319; no. 2; pp. 203 - 213
• Main Authors: Li, Chia-Jung, Chu, Ching-Yu, Huang, Lin-Huang, Wang, Ming-Hseng, Sheu, Lai-Fa, Yeh, Jih-I, Hsu, Hsue-Yin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Limited 28.06.2012
• Subjects: Animal models; Animals; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Antitumor activity; Apoptosis; Apoptosis - drug effects; Cancer therapies; Caspase-3; Cell culture; Cell growth; Cell Line, Tumor; Chemotherapy; Cisplatin; Cisplatin - administration & dosage; Cytochrome c; Cytotoxicity; Deoxyribonucleic acid; Diterpenes - administration & dosage; DNA; DNA damage; DNA repair; Drug dosages; Drug Synergism; Epoxy Compounds - administration & dosage; Gastric cancer; Hematology, Oncology and Palliative Medicine; Herbal medicines; Humans; Male; Membrane potential; Mice; Mice, SCID; Mitochondria; Mortality; Phenanthrenes - administration & dosage; Phytotherapy - methods; Plant Extracts; Proliferating cell nuclear antigen; Severe combined immunodeficiency; Side effects; Stomach Neoplasms - drug therapy; Studies; Therapeutic applications; Toxicity; Tripterygium; triptolide; Tumors; Xenograft Model Antitumor Assays; Xenografts; Xenograft; Synergism; Mitochondrial apoptotic pathway; Triptolide; Cisplatin

Abstract Cisplatin is an anticancer agent that is effective against several types of cancer, including gastric cancer. However, its therapeutic application is limited by its toxicity in normal tissues and complications caused in patients. In this study, we attempted to clarify how triptolide, an act...