Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma

• Published in: Clinical & experimental metastasis Vol. 22; no. 8; pp. 643 - 652
• Main Authors: Dass, Crispin R, Nadesapillai, Anne P W, Robin, Daniel, Howard, Monique L, Fisher, Jane L, Zhou, Hong, Choong, Peter F M
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.12.2005
• Subjects: Animals; Blotting, Western; Cell Division - physiology; Down-Regulation; Lung Neoplasms - secondary; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Receptors, Cell Surface - physiology; Receptors, Urokinase Plasminogen Activator

The uPA/uPAR system is involved in tumour progression and metastasis of a variety of cancers. Previously, we have shown that increased expression of urokinase plasminogen activator (uPA) correlated with malignancy grade in certain sarcomas. A study looking at in vivo inhibition of this system has no...