Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept

• Published in: Ecotoxicology and environmental safety Vol. 290; p. 117617
• Main Authors: Li, Jingjing, Zhang, Yanzhao, Wei, Mingyue, He, Junjie, Ma, Huifeng, Chen, Zilong, Duan, Jiajia, Liu, Chuanxin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.01.2025; Elsevier
• Subjects: AMP-Activated Protein Kinases - metabolism; AMPK/TSC1/mTOR/ULK1; Animals; Autophagy - drug effects; Autophagy-Related Protein-1 Homolog - metabolism; Female; multiomics; ovarian toxicity; Ovary - drug effects; Ovary - pathology; Oxidative Stress - drug effects; Podophyllotoxin; Podophyllotoxin - toxicity; Rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; TOR Serine-Threonine Kinases - metabolism; toxicological evidence chain (TEC) concept; Podophyllotoxin; ovarian toxicity; HIE; ALP; GO; SOD; toxicological evidence chain (TEC) concept; CHO; MDA; TEC; TG; PPT; TEE; AMPK/TSC1/mTOR/ULK1; AOE; ALB; KEGG; multiomics; TP; GSH; FC; LCMS; IPE

Podophyllotoxin is a compound with clinical effects, such as anticancer and antiacromegaly effects, but its systemic toxicity has led to extremely limited clinical application. Using the toxicological evidence chain (TEC) as a research method, our team constructed, for the first time, a rat model in...