Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept - Li, Jingjing; Zhang, Yanzhao; Wei, Mingyue; He, Junjie; Ma, Huifeng; Chen, Zilong; Duan, Jiajia; Liu, Chuanxin (Ecotoxicology and environmental safety, 2025)
Keywords: AMP-Activated Protein Kinases - metabolism; AMPK/TSC1/mTOR/ULK1; Animals; Autophagy - drug effects; Autophagy-Related Protein-1 Homolog - metabolism; Female; multiomics; ovarian toxicity; Ovary - drug effects; Ovary - pathology; Oxidative Stress - drug effects; Podophyllotoxin; Podophyllotoxin - toxicity; Rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; TOR Serine-Threonine Kinases - metabolism; toxicological evidence chain (TEC) concept; Podophyllotoxin; ovarian toxicity; HIE; ALP; GO; SOD; toxicological evidence chain (TEC) concept; CHO; MDA; TEC; TG; PPT; TEE; AMPK/TSC1/mTOR/ULK1; AOE; ALB; KEGG; multiomics; TP; GSH; FC; LCMS; IPE