Chronic thromboembolic pulmonary hypertension-associated dysfibrinogenemias exhibit disorganized fibrin structure

• Published in: Thrombosis research Vol. 132; no. 6; pp. 729 - 734
• Main Authors: Marsh, James J, Chiles, Peter G, Liang, Ni-Cheng, Morris, Timothy A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.12.2013
• Subjects: Afibrinogenemia - blood; Afibrinogenemia - etiology; Afibrinogenemia - pathology; Case-Control Studies; Cohort Studies; Confocal microscopy; Fibrin - metabolism; Fibrinogen; Fibrinogen - chemistry; Fibrinogen - metabolism; Fibrinolysis; Hematology, Oncology and Palliative Medicine; Humans; Hypertension, Pulmonary - blood; Hypertension, Pulmonary - complications; Hypertension, Pulmonary - pathology; Microscopy, Confocal; Models, Molecular; Protein Conformation; Pulmonary embolism; Thrombosis; Thrombosis - blood; Thrombosis - complications; Thrombosis - pathology; chronic thromboembolic pulmonary hypertension; CTVD; chronic thrombotic venous disease; Pulmonary embolism; Fibrinogen; Confocal microscopy; CTEPH; Fibrinolysis; Thrombosis

Abstract Introduction Mechanisms contributing to the pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) are poorly understood. This disorder is characterized by incomplete resolution of pulmonary perfusion defects resulting from acute venous thromboembolism. We previously identifi...