Acquisition and performance in a rat sequential reaction time task is not affected by subtotal ventral striatal 6-OHDA lesions

• Published in: Neuroscience letters Vol. 476; no. 1; pp. 27 - 31
• Main Authors: Eckart, M.T., Huelse-Matia, M.C., Loer, D., Schwarting, R.K.W.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 26.05.2010; Elsevier
• Subjects: 6-OHDA; Animals; Biological and medical sciences; Corpus Striatum - drug effects; Corpus Striatum - physiology; Dopamine; Dopamine - metabolism; Fundamental and applied biological sciences. Psychology; Instrumental behaviour; Male; Oxidopamine - toxicity; Primates; Rat; Rats; Rats, Wistar; Reaction Time - drug effects; Serial Learning; Serial reaction time task; Striatum; Vertebrates: nervous system and sense organs; Striatum; 6-OHDA; Instrumental behaviour; Dopamine; Serial reaction time task; Rat; Rodentia; Central nervous system; Basal ganglion; Corpus striatum; Catecholamine; Oxidopamine; Encephalon; Vertebrata; Mammalia; Animal; Neurotransmitter; Behavior; Lesion

Based on findings of experiments with humans, non-human primates and rodents, it is commonly accepted that dopaminergic basal ganglia processes play a crucial role in procedural and sequential learning. Primal evidence for this hypothesis came from serial reaction time tasks (SRTT) studies, demonstr...