Urea cycle gene expression is suppressed by PFOA treatment in rats

• Published in: Toxicology letters Vol. 197; no. 1; pp. 46 - 50
• Main Authors: Walters, M.W., Wallace, K.B.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.08.2010; Elsevier
• Subjects: Amino Acids - metabolism; Animals; Biological and medical sciences; Caprylates - toxicity; Carbamoyl-Phosphate Synthase (Ammonia) - metabolism; Fluorocarbons - toxicity; Gene Expression - drug effects; Liver - drug effects; Liver - enzymology; Liver - metabolism; Male; Medical sciences; Mitochondria; PFOA; PPAR alpha - metabolism; PPARα; Rats; Rats, Sprague-Dawley; Toxicology; Urea - metabolism; Urea cycle; Mitochondria; Urea cycle; PPARα; PFOA; Rat; Organic perhalocompound; Rodentia; Gene expression; Vertebrata; Mammalia; Treatment; Animal; Fluorine Organic compounds; PPARa
• ISSN: 0378-4274; 1879-3169; 1879-3169
• DOI: 10.1016/j.toxlet.2010.04.027

Perfluorooctanoic acid (PFOA), with an array of industrial uses, is one of the most common perfluoroalkyl acids. Resistance to biological degradation and a global distribution are characteristics that have caused PFOA to become a frequent subject of toxicological studies. PFOA treatment in rodents c...