Immune aberrations in children with Autism Spectrum Disorder: a case-control study from a tertiary care neuropsychiatric hospital in India

• Published in: Psychoneuroendocrinology Vol. 94; pp. 162 - 167
• Main Authors: Basheer, Salah, Venkataswamy, Manjunatha M., Christopher, Rita, Van Amelsvoort, Therese, Srinath, Shoba, Girimaji, Satish Chandra, Ravi, Vasanthapuram
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2018
• Subjects: Autism spectrum disorder; Autism Spectrum Disorder - immunology; Case-Control Studies; Child; Child, Preschool; Cross-Sectional Studies; Cytokines; Cytokines - blood; Dendrites - immunology; Female; Flow Cytometry; Humans; IL-17; IL-6; Immune dysfunction; Immunophenotyping; Immunophenotyping - methods; India; Inflammation - metabolism; Interleukin-17 - analysis; Interleukin-17 - blood; Interleukin-6 - analysis; Interleukin-6 - blood; Male; Monocytes - immunology; Myeloid Cells - metabolism; Myeloid dendritic cells; Prospective Studies; Tertiary Healthcare; Th17 cells; Th17 Cells - immunology; Th17 Cells - metabolism; Th17 Cells - physiology; India; Cytokines; Immune dysfunction; Myeloid dendritic cells; IL-17; Immunophenotyping; Autism spectrum disorder; IL-6; Th17 cells

•This is the first study to comprehensively evaluate various peripheral immune cell subsets coupled with associated serum cytokine levels in children with ASD.•Myeloid dendritic cells and activated Th17 cells were significantly elevated in children with ASD.•Serum IL-6 levels and IL-17 levels were h...