Revealing the core suppression effects of various Di (2-ethylhexyl) phthalate exposure on early meiosis progression in postnatal male mice via single-cell RNA sequencing

• Published in: Ecotoxicology and environmental safety Vol. 291; p. 117866
• Main Authors: Han, Baoquan, Hua, Lei, Yu, Shuai, Ge, Wei, Huang, Cong, Tian, Yu, Li, Chunxiao, Yan, Jiamao, Qiao, Tian, Guo, Jiachen, Lu, Dongliang, Wang, Bin, Cai, Diya, Zhang, Yunqi, Liang, Shaolin, Zhao, Jianjuan, Hou, Qi, Shen, Wei, Sun, Zhongyi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2025; Elsevier
• Subjects: Animals; Di (2-ethylhexyl) phthalate; Diethylhexyl Phthalate - toxicity; Early meiosis; Male; Meiosis - drug effects; Mice; P38 mitogen-activated protein kinase pathway; Plasticizers - toxicity; Reproductive toxicity; Sequence Analysis, RNA; Sertoli Cells - drug effects; Single-Cell Analysis; Single-cell RNA sequencing; Testis - drug effects; Trp53; P38 mitogen-activated protein kinase pathway; Early meiosis; Di (2-ethylhexyl) phthalate; Single-cell RNA sequencing; Trp53; Reproductive toxicity

The male reproductive system has been the subject of considerable attention in recent years due to the adverse effects of Di (2-ethylhexyl) phthalate (DEHP). Although previous research has suggested that DEHP exposure hinders the early meiotic progression of male germ cells, the underlying mechanism...