Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels

• Published in: Neurochemistry international Vol. 59; no. 6; pp. 896 - 905
• Main Authors: Barbon, Alessandro, Caracciolo, Luca, Orlandi, Cesare, Musazzi, Laura, Mallei, Alessandra, La Via, Luca, Bonini, Daniela, Mora, Cristina, Tardito, Daniela, Gennarelli, Massimo, Racagni, Giorgio, Popoli, Maurizio, Barlati, Sergio
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.11.2011; Elsevier
• Subjects: Animals; Antidepressant; Antidepressive Agents - administration & dosage; Antidepressive Agents - pharmacology; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Depressive Disorder - drug therapy; Drug Administration Schedule; Expression; Fluoxetine; Fundamental and applied biological sciences. Psychology; Glutamate receptors; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - physiopathology; Male; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Protein Subunits - biosynthesis; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Sprague-Dawley; Reboxetine; Receptors, AMPA - biosynthesis; RNA editing; Time Factors; Up-Regulation - drug effects; Up-Regulation - physiology; Vertebrates: nervous system and sense organs; Glutamate receptors; Antidepressant; Reboxetine; RNA editing; Expression; Fluoxetine; Chronic; AMPA receptor; Antidepressant agent; Glutamate receptor; Subunit; Protein

► ADs alter AMPAR transcriptional, post-transcriptional and translational regulations. ► AMPAR mRNAs and proteins are up-regulated with a specific temporal profile. ► Classical AD converge to regulate glutamatergic synaptic strength and plasticity. Growing evidence suggests a pivotal role for glutam...