Attenuation of Skeletal Muscle Atrophy Induced by Dexamethasone in Rats by Teaghrelin Supplementation

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 2; p. 688
• Main Authors: Jhuo, Cian-Fen, Hsieh, Sheng-Kuo, Chen, Wen-Ying, Tzen, Jason T. C.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.01.2023; MDPI
• Subjects: Akt phosphorylation; Animals; Atrophy; Autophagy; Dexamethasone - adverse effects; Dietary Supplements; Enzymes; Flavonoids; Growth hormones; Insulin resistance; Kinases; Metabolism; Muscle function; Muscle, Skeletal - metabolism; Muscular Atrophy - chemically induced; Muscular Atrophy - drug therapy; Muscular Atrophy - metabolism; Musculoskeletal system; Older people; Phosphorylation; protein degradation; Protein synthesis; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Rats; Rats, Sprague-Dawley; skeletal muscle atrophy; Steroids; teaghrelin; protein synthesis; Akt phosphorylation; skeletal muscle atrophy; teaghrelin; protein degradation

Muscle atrophy caused by an imbalance between the synthesis and the degradation of proteins is a syndrome commonly found in the elders. Teaghrelin, a natural compound from oolong tea, has been shown to promote cell differentiation and to inhibit dexamethasone-induced muscle atrophy in C2C12 cells. I...