Glucocorticoid-induced apoptosis and cellular mechanisms of myopathy
Glucocorticoid-induced myopathy is a common side effect of chronic glucocorticoid therapy. Several mechanisms are currently being examined as ways in which glucocorticoid-induced myopathy occurs. These include apoptotic signaling through mitochondrial-mediated and Fas-mediated apoptosis, the role of...
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| Published in | The Journal of steroid biochemistry and molecular biology Vol. 117; no. 1; pp. 1 - 7 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.10.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Glucocorticoid-induced myopathy is a common side effect of chronic glucocorticoid therapy. Several mechanisms are currently being examined as ways in which glucocorticoid-induced myopathy occurs. These include apoptotic signaling through mitochondrial-mediated and Fas-mediated apoptosis, the role of the proteosome, the suppression of the IGF-1 signaling, and the role of ceramide in glucocorticoid-induced apoptosis and myopathy. It is difficult to differentiate which mechanism may be the initiating event responsible for the induction of apoptosis; however, all of the mechanisms play a vital role in glucocorticoid-induced myopathy. |
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| AbstractList | Glucocorticoid-induced myopathy is a common side effect of chronic glucocorticoid therapy. Several mechanisms are currently being examined as ways in which glucocorticoid-induced myopathy occurs. These include apoptotic signaling through mitochondrial-mediated and Fas-mediated apoptosis, the role of the proteosome, the suppression of the IGF-1 signaling, and the role of ceramide in glucocorticoid-induced apoptosis and myopathy. It is difficult to differentiate which mechanism may be the initiating event responsible for the induction of apoptosis; however, all of the mechanisms play a vital role in glucocorticoid-induced myopathy. |
| Author | Dirks-Naylor, Amie J. Griffiths, Carrie L. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19520160$$D View this record in MEDLINE/PubMed |
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| Keywords | Atrophy Oxidative stress Mitochondria Cell death Skeletal muscle |
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| SubjectTerms | Animals Apoptosis - drug effects Atrophy Cell death Ceramides - metabolism fas Receptor - metabolism Glucocorticoids - adverse effects Humans Immunosuppressive Agents - adverse effects Insulin-Like Growth Factor I - metabolism Mitochondria Mitochondria, Muscle - drug effects Mitochondria, Muscle - metabolism Models, Biological Muscular Diseases - chemically induced Muscular Diseases - metabolism Muscular Diseases - pathology Oxidative stress Proteasome Endopeptidase Complex - metabolism Signal Transduction - drug effects Skeletal muscle |
| Title | Glucocorticoid-induced apoptosis and cellular mechanisms of myopathy |
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