A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations

• Published in: European journal of pharmacology Vol. 627; no. 1; pp. 85 - 91
• Main Authors: Lee, Hyun-Sub, Kim, Sung Dae, Lee, Whi Min, Endale, Mehari, Kamruzzaman, S.M., Oh, Won Jun, Cho, Jae Youl, Kim, Sang Keun, Cho, Hyun-Jeong, Park, Hwa-Jin, Rhee, Man Hee
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 10.02.2010; Elsevier
• Subjects: Adenosine Triphosphate - metabolism; Animals; Anti-Inflammatory Agents - pharmacology; BAY 11-7082; Biological and medical sciences; Blood Platelets - drug effects; Blood Platelets - metabolism; Calcium - metabolism; cAMP; Cell Adhesion Molecules - metabolism; Collagen - pharmacology; Cyclic AMP - biosynthesis; Cyclic AMP - metabolism; Cyclic GMP - biosynthesis; Cyclic GMP - metabolism; Gene Expression Regulation - drug effects; Intracellular Space - drug effects; Intracellular Space - metabolism; Male; MAP kinase; Medical sciences; Microfilament Proteins - metabolism; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 8 - metabolism; NF-kappa B - metabolism; Nitriles - pharmacology; P-Selectin - metabolism; Pharmacology. Drug treatments; Phosphoproteins - metabolism; Phosphorylation - drug effects; Platelet; Platelet Aggregation - drug effects; Rats; Rats, Sprague-Dawley; Sulfones - pharmacology; Thrombin - pharmacology; Thromboxane A2 - biosynthesis; TXA 2; VASP; VASP; MAP kinase; Platelet; BAY 11-7082; cAMP; TXA 2; Phosphorylation; Enzyme; Arachidonic acid derivatives; Transferases; Thromboxane A2; Cyclic AMP; Mitogen-activated protein kinase; Aggregation; Eicosanoid; AMP-3',5'; TXA

Platelets, though anucleated, possess several transcription factors, including NF-κB, that exert non-genomic functions regulating platelet activation. Since platelets have not only been recognized as central players of homeostasis, but also participated in pathological conditions such as thrombosis,...