Lipid peroxide and transition metals are required for the toxicity of oxidized low density lipoprotein to cultured endothelial cells

• Published in: Biochimica et biophysica acta Vol. 1096; no. 2; p. 155
• Main Authors: Kuzuya, M, Naito, M, Funaki, C, Hayashi, T, Asai, K, Kuzuya, F
• Format: Journal Article
• Language: English
• Published: Netherlands 22.02.1991
• Subjects: Animals; Cattle; Cells, Cultured; Copper - chemistry; Copper - metabolism; Endothelium, Vascular - drug effects; Fatty Acids, Unsaturated - chemistry; In Vitro Techniques; Lipid Peroxides - metabolism; Lipoproteins, LDL - chemistry; Lipoproteins, LDL - toxicity; Metals - chemistry; Metals - metabolism; Oxidation-Reduction

The toxicity of oxidized low density lipoprotein (Ox-LDL) to cultured vascular endothelial cells was investigated. The modification of low density lipoprotein (LDL) by copper led to the production of thiobarbituric acid-reacting substance (TBARS) and lipid hydroperoxide (LPO). TBARS was distributed...