Dimethyl Sulfoxide (DMSO) Decreases Cell Proliferation and TNF-α, IFN-γ, and IL-2 Cytokines Production in Cultures of Peripheral Blood Lymphocytes

• Published in: Molecules (Basel, Switzerland) Vol. 22; no. 11; p. 1789
• Main Authors: De Abreu Costa, Lucas, Henrique Fernandes Ottoni, Marcelo, Dos Santos, Michaelle, Meireles, Agnes, Gomes de Almeida, Valéria, De Fátima Pereira, Wagner, Alves de Avelar-Freitas, Bethânia, Eustáquio Alvim Brito-Melo, Gustavo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.11.2017; MDPI
• Subjects: anti-inflammatory agents; Cell Death - drug effects; Cell Proliferation - drug effects; Cells, Cultured; Cytokines; dimethyl sulfoxide; Dimethyl Sulfoxide - pharmacology; Hemolysis - drug effects; Humans; Interferon-gamma - biosynthesis; Interleukin-2 - biosynthesis; Lymphocyte receptors; Lymphocytes; Lymphocytes - cytology; Lymphocytes - drug effects; Lymphocytes - metabolism; solvents; T cell receptors; Tumor Necrosis Factor-alpha - biosynthesis; Tumor necrosis factor-TNF; anti-inflammatory agents; solvents; dimethyl sulfoxide

Dimethylsulfoxide (DMSO) is an amphipathic molecule composed of a polar domain characterized by the sulfinyl and two nonpolar methyl groups, for this reason it is able to solubilize polar and nonpolar substances and transpose hydrophobic barriers. DMSO is widely used to solubilize drugs of therapeut...