Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis

• Published in: Journal of neuroimmunology Vol. 338; p. 577090
• Main Authors: Kolić, Ivana, Stojković, Ljiljana, Dinčić, Evica, Jovanović, Ivan, Stanković, Aleksandra, Živković, Maja
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2020
• Subjects: Inflammation; Leptin; mRNA expression; Multiple sclerosis; Oxidative response; Peripheral blood mononuclear cells; RRMS; Multiple sclerosis; MSSS; MS; CNS; Inflammation; mRNA; SOD2; PBMC; mRNA expression; TNFA; pLEP; PGC1A; Leptin; LEP; ROS; Peripheral blood mononuclear cells; LEPR; Oxidative response; PPIA; EDSS; BMI

Leptin (LEP) may contribute to the pathogenesis of multiple sclerosis (MS) by its immunomodulatory, proinflammatory and prooxidant effects. Therefore, plasma LEP levels and mRNA expression of five genes related to the LEP signaling pathway (LEP, LEP receptor (LEPR), peroxisome proliferator-activated...