Loss of Drosha underlies dopaminergic neuron toxicity in models of Parkinson's disease

• Published in: Cell death & disease Vol. 9; no. 6; pp. 693 - 12
• Main Authors: Wang, Ronglin, Lu, Fangfang, Zhu, Gang, Feng, Dayun, Nie, Tiejian, Tao, Kai, Yang, Shaosong, Lei, Jie, Huang, Lu, Mao, Zixu, Yang, Qian
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 07.06.2018; Nature Publishing Group UK
• Subjects: Animal models; Cell death; Cell survival; Dopamine receptors; Gene expression; MAP kinase; miRNA; Movement disorders; Neurodegenerative diseases; Parkinson's disease; Phosphorylation; Toxicity

MiRNAs, a group of powerful modulator of gene expression, participate in multiple cellular processes under physiological and pathological conditions. Emerging evidence shows that Drosha, which controls the initial step in canonical miRNA biogenesis, is involved in modulating cell survival and death...