Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA

• Published in: Structure (London) Vol. 31; no. 8; pp. 958 - 967.e3
• Main Authors: Cheung, Timothy C., Atwell, Shane, Bafetti, Lisa, Cuenca, Paulina Delgado, Froning, Karen, Hendle, Jorg, Hickey, Michael, Ho, Carolyn, Huang, Jiawen, Lieu, Ricky, Lim, Stacie, Lippner, David, Obungu, Victor, Ward-Kavanagh, Lindsay, Weichert, Kenneth, Ware, Carl F., Vendel, Andrew C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 03.08.2023; Elsevier
• Subjects: agonist antibody; Animals; Antibodies - metabolism; autoimmune disease; B and T lymphocyte attenuator; BASIC BIOLOGICAL SCIENCES; Biochemistry & Molecular Biology; Biophysics; BTLA; Cell Biology; checkpoint inhibitory receptor; herpesvirus entry mediator; Mice; NF-κB inhibition; Receptors, Immunologic - metabolism; T cells; T-Lymphocytes - metabolism; TNFRSF14; checkpoint inhibitory receptor; agonist antibody; B and T lymphocyte attenuator; BTLA; herpesvirus entry mediator; TNFRSF14; NF-κB inhibition; T cells; autoimmune disease

B and T lymphocyte attenuator (BTLA) is an attractive target for a new class of therapeutics that attempt to rebalance the immune system by agonizing checkpoint inhibitory receptors (CIRs). Herpesvirus entry mediator (HVEM) binds BTLA in both trans- and cis-orientations. We report here the developme...