SUCCESSFUL UNRELATED UMBILICAL CORD BLOOD TRANSPLANTATION IN A CHILD WITH OMENN'S SYNDROME

• Published in: Pediatric hematology and oncology Vol. 16; no. 4; pp. 361 - 366
• Main Authors: Benito, A., Diaz, M. A., Alonso, F., Fontan, G., Madero, L.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Informa UK Ltd 01.07.1999; Taylor & Francis
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone marrow, stem cells transplantation. Graft versus host reaction; Cord Blood Transplantation; Eosinophilia - therapy; Fetal Blood; Hematopoietic Stem Cell Transplantation; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infant; Lymphatic Diseases - genetics; Lymphatic Diseases - therapy; Male; Medical sciences; Omenn'S Syndrome; Syndrome; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation Conditioning; Unrelated Donor; Human; Immunopathology; Histocompatibility system; Unrelated donor; Leukocyte; Treatment efficiency; Male; Transplantation; Immune deficiency; Case study; Platelet; Newborn; Surgery; Umbilical cord

Omenn's syndrome is a variant of combined immunodeficiency disease (CID). Like other CID forms, it causes death unless the patient receives a bone marrow transplant (BMT). Previous reports have shown that BMTs from unrelated donors in Omenn's syndrome have very poor results, with a high ra...