Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration?

• Published in: Neurology Vol. 75; no. 24; p. 2212
• Main Authors: Whitwell, J L, Jack, Jr, C R, Parisi, J E, Senjem, M L, Knopman, D S, Boeve, B F, Rademakers, R, Baker, M, Petersen, R C, Dickson, D W, Josephs, K A
• Format: Journal Article
• Language: English
• Published: United States 14.12.2010
• Subjects: Adult; Aged; Aged, 80 and over; Atrophy; Brain - metabolism; Brain - pathology; Case-Control Studies; DNA-Binding Proteins - classification; DNA-Binding Proteins - metabolism; Female; Frontal Lobe - metabolism; Frontal Lobe - pathology; Frontotemporal Lobar Degeneration - metabolism; Frontotemporal Lobar Degeneration - pathology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parietal Lobe - metabolism; Parietal Lobe - pathology; Risk Factors; Temporal Lobe - metabolism; Temporal Lobe - pathology

To determine whether TDP-43 type is associated with distinct patterns of brain atrophy on MRI in subjects with pathologically confirmed frontotemporal lobar degeneration (FTLD). In this case-control study, we identified all subjects with a pathologic diagnosis of FTLD with TDP-43 immunoreactive incl...