The Effects of Propofol on a Human in vitro Blood-Brain Barrier Model

• Published in: Frontiers in cellular neuroscience Vol. 16; p. 835649
• Main Authors: Hughes, Jason M, Neese, Olivia R, Bieber, Dylan D, Lewis, Kirsten A, Ahmadi, Layla M, Parsons, Dustin W, Canfield, Scott G
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 11.05.2022; Frontiers Media S.A
• Subjects: Alzheimer's disease; Anesthesia; anesthesia toxicity; Anesthetics; Blood-brain barrier; brain microvascular-like endothelial cells; Dextran; Electrical resistivity; Endothelial cells; Localization; Matrix metalloproteinase; Metalloproteinase; Microvasculature; Neurodegenerative diseases; Neuroscience; Parenchyma; Permeability; Pluripotency; Propofol; Proteins; Sodium; Stem cells; tight junction dysfunction; St Louis Missouri; United States > US; blood-brain barrier; tight junction dysfunction; propofol; brain microvascular-like endothelial cells; anesthesia toxicity

Recently, the safety of repeated and lengthy anesthesia administration has been called into question, a subset of these animal studies demonstrated that anesthetics induced blood-brain barrier (BBB) dysfunction. The BBB is critical in protecting the brain parenchyma from the surrounding micro-vascul...