DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway

• Published in: Science signaling Vol. 15; no. 715; p. eabh2290
• Main Authors: Liu, Liu, Dai, Xiaoming, Yin, Shasha, Liu, Pengda, Hill, Elizabeth G, Wei, Wenyi, Gan, Wenjian
• Format: Journal Article
• Language: English
• Published: United States 04.01.2022
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; DNA Damage; Mechanistic Target of Rapamycin Complex 2 - genetics; Mechanistic Target of Rapamycin Complex 2 - metabolism; Phosphorylation; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; TOR Serine-Threonine Kinases - metabolism

The kinase AKT (also known as protein kinase B) is a key regulator of cell proliferation, survival, and metabolism. In addition to being activated by growth factors, AKT is activated in response to DNA damage. Here, we found that the DNA damage response kinase DNA-PK sustains cell survival through a...