Direct effects of glucagon on glucose uptake and lipolysis in human adipocytes

• Published in: Molecular and cellular endocrinology Vol. 503; p. 110696
• Main Authors: Pereira, Maria J., Thombare, Ketan, Sarsenbayeva, Assel, Kamble, Prasad G., Almby, Kristina, Lundqvist, Martin, Eriksson, Jan W.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.03.2020
• Subjects: adipocytes; Adipocytes - drug effects; Adipocytes - metabolism; Adipocytes - pathology; Adipose tissue; Adipose Tissue - metabolism; Adipose Tissue - pathology; Adult; Aged; body mass index; Carbohydrate Metabolism - drug effects; Case-Control Studies; Cells, Cultured; Cohort Studies; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Female; gene expression; Gene Expression - drug effects; genes; Glucagon; Glucagon - pharmacology; Glucagon receptor; glucagon receptors; glucose; Glucose - metabolism; Glucose uptake; Humans; insulin; insulin resistance; Lipolysis; Lipolysis - drug effects; Male; Metabolism; Middle Aged; Primary Cell Culture; Receptors, Glucagon - genetics; Receptors, Glucagon - metabolism; Glucose uptake; Glucagon receptor; Adipose tissue; Glucagon; Metabolism; Lipolysis

We aim to investigate the expression of the glucagon receptor (GCGR) in human adipose tissue, and the impact of glucagon in glucose uptake and lipolysis in human adipocytes. GCGR gene expression in human subcutaneous and visceral adipose tissue was demonstrated, albeit at low levels and with an inte...