UBE2L3 promotes benzene-induced hematotoxicity via autophagy-dependent ferroptosis

• Published in: Ecotoxicology and environmental safety Vol. 283; p. 116773
• Main Authors: Wang, Boshen, Li, Fei, Hu, Juan, Sun, Fengmei, Han, Lei, Zhang, Juan, Zhu, Baoli
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.09.2024; Elsevier
• Subjects: Adult; Autophagy - drug effects; Autophagy-dependent ferroptosis; Benzene; Benzene - toxicity; Environmental Pollutants - toxicity; Female; Ferroptosis - drug effects; Hematotoxicity; Humans; Male; Prospective Studies; UBE2L3; Ubiquitin-Conjugating Enzymes - genetics; Ubiquitin-Conjugating Enzymes - metabolism; Autophagy-dependent ferroptosis; Hematotoxicity; Benzene; UBE2L3

Benzene is a common environmental pollutant and significant health hazard. Low-dose benzene exposure is common in most industrial settings, and some workers exhibit hematotoxicity characterized by impaired hematopoietic function. Consequently, understanding the early hematopoietic damage and biomark...