Most CD4+ T cells from human immunodeficiency virus-1 infected patients can undergo prolonged clonal expansion

• Published in: The Journal of clinical investigation Vol. 84; no. 5; pp. 1637 - 1643
• Main Authors: LANGHOFF, E, MCELRATH, J, BOS, H. J, PRUETT, J, GRANELI-PIPERNO, A, COHN, Z. A, STEINMAN, R. M
• Format: Journal Article
• Language: English
• Published: Ann Arbor, MI American Society for Clinical Investigation 01.11.1989
• Subjects: Acquired Immunodeficiency Syndrome - blood; AIDS/HIV; Antigens, CD - analysis; Antigens, Differentiation, T-Lymphocyte; Biological and medical sciences; CD4 Antigens - analysis; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - microbiology; CD4-Positive T-Lymphocytes - pathology; CD8 Antigens; Cell Division; Clone Cells - pathology; Dendritic Cells - physiology; HIV-1 - genetics; HIV-1 - growth & development; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Interleukin-2 - pharmacology; Male; Medical sciences; Nucleic Acid Hybridization; Phytohemagglutinins - pharmacology; RNA, Messenger - analysis; RNA, Viral - analysis; Infection; Human; Cell proliferation; AIDS; Viral disease; T-Lymphocyte

We have addressed the capacity of HIV-1 infection to alter the growth of primary CD4+ T cells, but at the clonal level. Single T cells were expanded in the presence of PHA, IL-2, and small numbers of accessory dendritic cells. We report two new findings. First, T cells from seropositive individuals,...