A Randomized, Double-Blind, Placebo-Controlled Trial of Single-Dose Ciprofloxacin versus Erythromycin for the Treatment of Chancroid in Nairobi, Kenya

• Published in: The Journal of infectious diseases Vol. 180; no. 6; pp. 1886 - 1893
• Main Authors: Malonza, Isaac M., Tyndall, Mark W., Ndinya-Achola, Jeckoniah O., Maclean, Ian, Omar, Siad, MacDonald, Kelly S., Perriens, Jos, Orle, Karina, Plummer, Francis A., Ronald, Allan R., Moses, Stephen
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.12.1999; University of Chicago Press; Oxford University Press
• Subjects: Adolescent; Adult; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Chancroid; Chancroid - drug therapy; Chancroid - microbiology; Chancroid - virology; Ciprofloxacin - administration & dosage; Ciprofloxacin - therapeutic use; Double-Blind Method; Erythromycin - administration & dosage; Erythromycin - therapeutic use; Etiology; Female; Genitalia; Haemophilus ducreyi - genetics; Haemophilus ducreyi - isolation & purification; Herpes Genitalis - virology; HIV 1; HIV Infections - complications; Humans; Infections; Kenya; Major Articles; Male; Medical sciences; Men; Middle Aged; Pharmacology. Drug treatments; Polymerase Chain Reaction; Simplexvirus; Simplexvirus - genetics; Simplexvirus - isolation & purification; Syphilis; Syphilis - complications; Syphilis - microbiology; Treatment Outcome; Treponema pallidum - genetics; Treponema pallidum - isolation & purification; Ulcers; Kenya; Africa; Human; Treatment efficiency; Erythromycin; Macrolide; Infection; Pasteurellaceae; Fluoroquinolone derivatives; Antibiotic; Chemotherapy; Sexually transmitted disease; Treatment; Chancroid; Bacteriosis; Bacteria; Clinical trial; Antibacterial agent; Ciprofloxacin; Quinolone derivatives; Haemophilus ducreyi

A randomized, double-blind, placebo-controlled clinical trial was conducted in Nairobi, Kenya, to compare single-dose ciprofloxacin with a 7-day course of erythromycin for the treatment of chancroid. In all, 208 men and 37 women presenting with genital ulcers clinically compatible with chancroid wer...