Branched-chain 2-oxo acid dehydrogenase complex activation by tetanic contractions in rat skeletal muscle

• Published in: Biochimica et biophysica acta Vol. 1157; no. 2; pp. 290 - 296
• Main Authors: Shimomura, Yoshiharu, Fujii, Hisao, Suzuki, Masashige, Fujitsuka, Noriaki, Naoi, Makoto, Sugiyama, Satoru, Harris, Robert A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 11.07.1993
• Subjects: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adenosine Diphosphate - analysis; Adenosine Monophosphate - analysis; Adenosine Triphosphate - analysis; Animals; Branched-chain 2-oxo acid dehyrogenase complex; Branched-chain 2-oxo acids; Branched-chain amino acid; Electric Stimulation; Enzyme Activation; Female; Inosine Monophosphate - analysis; Ketone Oxidoreductases - metabolism; Lactate; Lactates - analysis; Lactic Acid; Multienzyme Complexes - metabolism; Muscle; Muscle Contraction; Rats; Rats, Sprague-Dawley; Tetanic contraction; Branched-chain 2-oxo acid dehyrogenase complex; Tetanic contraction; BCODH; Lactate; Muscle; Branched-chain amino acid; Branched-chain 2-oxo acids; BCAA
• ISSN: 0304-4165; 0006-3002; 1872-8006
• DOI: 10.1016/0304-4165(93)90112-L

Branched-chain 2-oxo acid dehydrogenase complex in rat skeletal muscle was activated by muscle contractions elicited by electrical stimulation. This activation was attributed to dephosphorylation of the phosphorylated enzyme complex, and the total enzyme activity was not altered by muscle contractio...