Reproducible features of small RNAs in C. elegans reveal NU RNAs and provide insights into 22G RNAs and 26G RNAs

• Published in: RNA (Cambridge) Vol. 22; no. 2; pp. 184 - 192
• Main Authors: Blumenfeld, Andrew L., Jose, Antony M.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.02.2016
• Subjects: Animals; Bioinformatics; Caenorhabditis elegans - genetics; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - genetics; Caenorhabditis elegans Proteins - metabolism; Gene Silencing; Molecular Sequence Data; Nucleotide Motifs; Ribonuclease III - genetics; Ribonuclease III - metabolism; RNA Replicase - genetics; RNA Replicase - metabolism; RNA, Double-Stranded - genetics; RNA, Double-Stranded - metabolism; RNA, Small Interfering - chemistry; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; RNA-seq; gene silencing; RNAi

Small RNAs regulate gene expression and most genes in the worm Caenorhabditis elegans are subject to their regulation. Here, we analyze small RNA data sets and use reproducible features of RNAs present in multiple data sets to discover a new class of small RNAs and to reveal insights into two known...