Angiotensin-(1-7) attenuates damage to podocytes induced by preeclamptic serum through MAPK pathways

• Published in: International journal of molecular medicine Vol. 34; no. 4; pp. 1057 - 1064
• Main Authors: TIAN, JIMEI, ZHANG, LIHONG, ZHOU, YUNJIAO, XIAO, JING, LI, SHERAN, CHEN, YAPING, QIAO, ZHONGDONG, NIU, JIANYING, GU, YONG
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.10.2014; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Abnormalities; Actins - metabolism; Adult; Age; Analysis; Angiotensin; Angiotensin I - pharmacology; Angiotensin II - analogs & derivatives; Angiotensin II - pharmacology; angiotensin-(1-7); Apoptosis; Apoptosis - drug effects; Birth weight; Cell Survival - drug effects; Diabetes; Drug dosages; Enzyme activation; Epithelium; Female; Genetic aspects; Humans; Hypertension; Intracellular Signaling Peptides and Proteins - metabolism; Kidney diseases; Kinases; MAP Kinase Signaling System - drug effects; Membrane Proteins - metabolism; mitogen-activated protein kinase phosphorylation; Mitogen-Activated Protein Kinases - metabolism; Pathogenesis; Peptide Fragments - pharmacology; Phosphorylation; Phosphorylation - drug effects; podocyte; Podocytes - drug effects; Podocytes - enzymology; Podocytes - pathology; Pre-Eclampsia - blood; Pre-Eclampsia - enzymology; Preeclampsia; Pregnancy; Properties; Proteins; Proto-Oncogene Proteins - metabolism; Receptors, G-Protein-Coupled - metabolism; Rodents; Studies; Uric acid; Urine; Womens health

The underlying mechanisms of proteinuria, a main characteristic of preeclampsia (PE), have not yet been fully elucidated. Evidence indicates that the renin-angiotensin system (RAS) is involved in the pathogenesis of this disease, including decreased angiotensin-(1-7) [Ang-(1-7)] levels in the circul...