Hexavalent chromium induced metabolic reprogramming, carcinogenesis and tumor progression through PDK1 upregulation - Liu, Wen-Jing; Wang, Lin; Sun, Fan-Li; Zhou, Feng-Mei; Zhang, Rui-Ke; Liu, Jie; Zhao, Min; Wang, Li-Hong; Qin, Yan-Ru; Zhao, Yan-Qiu; Qiu, Jian-Ge; Jiang, Bing-Hua (Ecotoxicology and environmental safety, 2024)
Keywords: 3-Phosphoinositide-Dependent Protein Kinases - genetics; 3-Phosphoinositide-Dependent Protein Kinases - metabolism; Animals; Carcinogenesis - chemically induced; Carcinogenesis, lung cancer development; Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Chromium - toxicity; Hexavalent chromium; HIF-1α; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Lung Neoplasms - chemically induced; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Metabolic Reprogramming; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; MiR-493; PDK1; Pyruvate Dehydrogenase Acetyl-Transferring Kinase - metabolism; Up-Regulation - drug effects; Hexavalent chromium; MiR-493; HIF-1α; Carcinogenesis, lung cancer development; PDK1