Associations of urinary cadmium with circulating sex hormone levels in pre- and postmenopausal Japanese women

• Published in: Environmental research Vol. 150; pp. 82 - 87
• Main Authors: Nagata, Chisato, Konishi, Kie, Goto, Yuko, Tamura, Takashi, Wada, Keiko, Hayashi, Makoto, Takeda, Noriyuki, Yasuda, Keigo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2016
• Subjects: 60 APPLIED LIFE SCIENCES; Adult; alcohol drinking; body mass index; Breast cancer; breast neoplasms; CADMIUM; Cadmium - urine; Chromatography, Liquid; creatinine; Cross-Sectional Studies; Environmental Pollutants - urine; ESTRADIOL; Female; follicle-stimulating hormone; FSH; Gonadal Steroid Hormones - blood; Humans; HYDROXYANDROSTENONE; Japan; Japanese people; Japanese women; LIQUID COLUMN CHROMATOGRAPHY; luteinization; LUTEINIZING HORMONE; MASS SPECTROSCOPY; MENSTRUAL CYCLE; Middle Aged; NEOPLASMS; postmenopause; Postmenopause - blood; Postmenopause - urine; prasterone; premenopause; Premenopause - blood; Premenopause - urine; risk factors; sex hormone-binding globulin; smoking (habit); Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; TESTOSTERONE; urine; WOMEN; LC-MS/MS; Cadmium; Testosterone; DHEAS; Japanese women; FSH; Breast cancer; LH; SHBG; Estradiol

Exposure to cadmium has been suspected as a risk factor for breast cancer. The present study examined the associations between urinary cadmium levels and circulating sex hormone levels that are linked to breast cancer risk in healthy women. The study subjects were 396 premenopausal Japanese women wh...