Developing Translational Vaccines against Heroin and Fentanyl through Investigation of Adjuvants and Stability

• Published in: Molecular pharmaceutics Vol. 18; no. 1; pp. 228 - 235
• Main Authors: Blake, Steven, Bremer, Paul T, Zhou, Bin, Petrovsky, Nikolai, Smith, Lauren C, Hwang, Candy S, Janda, Kim D
• Format: Journal Article
• Language: English
• Published: United States 04.01.2021
• Subjects: Adjuvants, Immunologic - pharmacology; Adjuvants, Pharmaceutic - pharmacology; Analgesics, Opioid - immunology; Animals; Fentanyl - immunology; Heroin - immunology; Immunization - methods; Male; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides - immunology; Opioid-Related Disorders - immunology; Vaccination - methods; Vaccines, Conjugate - immunology; vaccine; heroin; fentanyl; carrier protein; immunopharmacotherapy; adjuvants; opioids

The nearly insurmountable adversity that accompanies opioid use disorder (OUD) creates life-altering complications for opioid users. To worsen matters, existing small-molecule drugs continue to inadequately address OUD due to their engagement of the opioid receptor, which can leave the user to deal...