He Jie Tang in the treatment of chronic hepatitis B patients
To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients. Eighty-five patients with chronic hepatitis B were divided randomly into two groups. Fifty patients in group I were treated with He...
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Published in | World journal of gastroenterology : WJG Vol. 11; no. 42; pp. 6638 - 6643 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China%Institute of Digestive Diseases, Traditional Chinese Medicine University of Guangzhou, Guangzhou 510405,Guangdong Province, China%Institute of virus, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany%Department of General Surgery, University of Essen,Hufelandstrasse 55, 45122 Essen, Germany
14.11.2005
Baishideng Publishing Group Inc |
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Abstract | To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients.
Eighty-five patients with chronic hepatitis B were divided randomly into two groups. Fifty patients in group I were treated with He Jie Tang (HJT) and 35 patients in group II were treated with combined medication. The levels of T-lymphocyte subsets (CD(3)(+), CD(4)(+), CD(8)(+)), NK cell activity, cytokines (TNF-alpha, IL-8, sIL-2R) were observed before and after the treatment. Another 20 normal persons served as group 3.
The level of CD(4)(+) cells and NK cell activity were lower, whereas the level of CD(8)(+) cells in patients was higher than that in normal persons (t = 2.685, 3.172, and 2.754 respectively; P<0.01). The levels of TNF-alpha, IL-8, and sIL-2R in chronic hepatitis B patients were higher than those in normal persons (t = 3.526, 3.170, and 2.876 respectively; P<0.01). After 6 months of treatment, ALT, AST, and TB levels in the two groups were obviously decreased (t = 3.421, 3.106, and 2.857 respectively; P<0.01). The level of CD(4)(+) cells and NK cell activity were increased whereas the level of CD(8)(+) cells decreased (t = 2.179, 2.423, and 2.677 respectively; P<0.05) in group I. The levels of TNF-alpha, IL-8, and sIL-2R in group I were decreased significantly after the treatment (t = 2.611, 2.275, and 2.480 respectively; P<0.05) but had no significant difference in group II after the treatment (t = 1.906, 1.833, and 2.029 respectively; P>0.05). The total effective rate had no significant difference between the two groups (c2 = 2.882, P>0.05) but the markedly effective rate was significantly different between the two groups (c2 = 5.340, P<0.05).
HJT is effective in treating chronic hepatitis B. HJT seems to exert its effect by improving the cellular immune function and decreasing inflammatory cytokines in chronic hepatitis B patients. The function of HJT in protecting liver function in the process of eliminating virus needs to be further studied. |
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AbstractList | To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients.
Eighty-five patients with chronic hepatitis B were divided randomly into two groups. Fifty patients in group I were treated with He Jie Tang (HJT) and 35 patients in group II were treated with combined medication. The levels of T-lymphocyte subsets (CD(3)(+), CD(4)(+), CD(8)(+)), NK cell activity, cytokines (TNF-alpha, IL-8, sIL-2R) were observed before and after the treatment. Another 20 normal persons served as group 3.
The level of CD(4)(+) cells and NK cell activity were lower, whereas the level of CD(8)(+) cells in patients was higher than that in normal persons (t = 2.685, 3.172, and 2.754 respectively; P<0.01). The levels of TNF-alpha, IL-8, and sIL-2R in chronic hepatitis B patients were higher than those in normal persons (t = 3.526, 3.170, and 2.876 respectively; P<0.01). After 6 months of treatment, ALT, AST, and TB levels in the two groups were obviously decreased (t = 3.421, 3.106, and 2.857 respectively; P<0.01). The level of CD(4)(+) cells and NK cell activity were increased whereas the level of CD(8)(+) cells decreased (t = 2.179, 2.423, and 2.677 respectively; P<0.05) in group I. The levels of TNF-alpha, IL-8, and sIL-2R in group I were decreased significantly after the treatment (t = 2.611, 2.275, and 2.480 respectively; P<0.05) but had no significant difference in group II after the treatment (t = 1.906, 1.833, and 2.029 respectively; P>0.05). The total effective rate had no significant difference between the two groups (c2 = 2.882, P>0.05) but the markedly effective rate was significantly different between the two groups (c2 = 5.340, P<0.05).
HJT is effective in treating chronic hepatitis B. HJT seems to exert its effect by improving the cellular immune function and decreasing inflammatory cytokines in chronic hepatitis B patients. The function of HJT in protecting liver function in the process of eliminating virus needs to be further studied. AIM: To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients. METHODS: Eighty-five patients with chronic hepatitis B were divided randomly into two groups. Fifty patients in group I were treated with He Jie Tang (HJT) and 35 patients in group II were treated with combined medication. The levels of T-lymphocyte subsets (CD 3 + , CD 4 + , CD 8 + ), NK cell activity, cytokines (TNF-α, IL-8, sIL-2R) were observed before and after the treatment. Another 20 normal persons served as group 3. RESULTS: The level of CD 4 + cells and NK cell activity were lower, whereas the level of CD 8 + cells in patients was higher than that in normal persons ( t = 2.685, 3.172, and 2.754 respectively; P <0.01). The levels of TNF-α, IL-8, and sIL-2R in chronic hepatitis B patients were higher than those in normal persons ( t = 3.526, 3.170, and 2.876 respectively; P <0.01). After 6 months of treatment, ALT, AST, and TB levels in the two groups were obviously decreased ( t = 3.421, 3.106, and 2.857 respectively; P <0.01). The level of CD 4 + cells and NK cell activity were increased whereas the level of CD 8 + cells decreased ( t = 2.179, 2.423, and 2.677 respectively; P <0.05) in group I. The levels of TNF-α, IL-8, and sIL-2R in group I were decreased significantly after the treatment ( t = 2.611, 2.275, and 2.480 respectively; P <0.05) but had no significant difference in group II after the treatment ( t = 1.906, 1.833, and 2.029 respectively; P >0.05). The total effective rate had no significant difference between the two groups (X 2 = 2.882, P >0.05) but the markedly effective rate was significantly different between the two groups (X 2 = 5.340, P <0.05). CONCLUSION: HJT is effective in treating chronic hepatitis B. HJT seems to exert its effect by improving the cellular immune function and decreasing inflammatory cytokines in chronic hepatitis B patients. The function of HJT in protecting liver function in the process of eliminating virus needs to be further studied. R5; AIM: To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients.METHODS: Eighty-five patients with chronic hepatitis B were divided randomly into two groups. Fifty patients in group Ⅰ were treated with He Jie Tang (HJT) and 35 patients in group Ⅱ were treated with combined medication. The levels of T-lymphocyte subsets (CD3+,CD4+, CD8+), NK cell activity, cytokines (TNF-α, IL-8,sIL-2R) were observed before and after the treatment.Another 20 normal persons served as group 3.RESULTS: The level of CD4+ cells and NK cell activity were lower, whereas the level of CD8+ cells in patients was higher than that in normal persons (t = 2.685,3.172, and 2.754 respectively; P<0.01). The levels of TNF-α, IL-8, and sIL-2R in chronic hepatitis B patients were higher than those in normal persons (t = 3.526,3.170, and 2.876 respectively; P<0.01). After 6 months of treatment, ALT, AST, and TB levels in the two groups were obviously decreased (t = 3.421, 3.106, and 2.857respectively; P<0.01). The level of CD4+ cells and NK cell activity were increased whereas the level of CD8+ cells decreased (t = 2.179, 2.423, and 2.677 respectively;P<0.05) in group I. The levels of TNF-α, IL-8, and sIL-2R in group Ⅰ were decreased significantly after the treatment (t = 2.611, 2.275, and 2.480 respectively;P<0.05) but had no significant difference in group Ⅱ after the treatment (t = 1.906, 1.833, and 2.029respectively; P>0.05). The total effective rate had no significant difference between the two groups (x2 = 2.882,P>0.05) but the markedly effective rate wass ignificantly different between the two groups (x2 = 5.340, P<0.05).CONCLUSION: HJT is effective in treating chronic hepatitis B. HJT seems to exert its effect by improving the cellular immune function and decreasing inflammatory cytokines in chronic hepatitis B patients.The function of HJT in protecting liver function in the process of eliminating virus needs to be further studied. AIMTo explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients.METHODSEighty-five patients with chronic hepatitis B were divided randomly into two groups. Fifty patients in group I were treated with He Jie Tang (HJT) and 35 patients in group II were treated with combined medication. The levels of T-lymphocyte subsets (CD(3)(+), CD(4)(+), CD(8)(+)), NK cell activity, cytokines (TNF-alpha, IL-8, sIL-2R) were observed before and after the treatment. Another 20 normal persons served as group 3.RESULTSThe level of CD(4)(+) cells and NK cell activity were lower, whereas the level of CD(8)(+) cells in patients was higher than that in normal persons (t = 2.685, 3.172, and 2.754 respectively; P<0.01). The levels of TNF-alpha, IL-8, and sIL-2R in chronic hepatitis B patients were higher than those in normal persons (t = 3.526, 3.170, and 2.876 respectively; P<0.01). After 6 months of treatment, ALT, AST, and TB levels in the two groups were obviously decreased (t = 3.421, 3.106, and 2.857 respectively; P<0.01). The level of CD(4)(+) cells and NK cell activity were increased whereas the level of CD(8)(+) cells decreased (t = 2.179, 2.423, and 2.677 respectively; P<0.05) in group I. The levels of TNF-alpha, IL-8, and sIL-2R in group I were decreased significantly after the treatment (t = 2.611, 2.275, and 2.480 respectively; P<0.05) but had no significant difference in group II after the treatment (t = 1.906, 1.833, and 2.029 respectively; P>0.05). The total effective rate had no significant difference between the two groups (c2 = 2.882, P>0.05) but the markedly effective rate was significantly different between the two groups (c2 = 5.340, P<0.05).CONCLUSIONHJT is effective in treating chronic hepatitis B. HJT seems to exert its effect by improving the cellular immune function and decreasing inflammatory cytokines in chronic hepatitis B patients. The function of HJT in protecting liver function in the process of eliminating virus needs to be further studied. |
Author | Chen, Ze-Xiong Guan, Shi-He Zhang, Shi-Jun Zhang, Cui-Yi Hu, Hong-Tao Lao, Shao-Xian Gu, Yan-Li |
AuthorAffiliation | Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China%Institute of Digestive Diseases, Traditional Chinese Medicine University of Guangzhou, Guangzhou 510405,Guangdong Province, China%Institute of virus, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany%Department of General Surgery, University of Essen,Hufelandstrasse 55, 45122 Essen, Germany |
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Author_xml | – sequence: 1 givenname: Ze-Xiong surname: Chen fullname: Chen, Ze-Xiong organization: Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China – sequence: 2 givenname: Shi-Jun surname: Zhang fullname: Zhang, Shi-Jun – sequence: 3 givenname: Shao-Xian surname: Lao fullname: Lao, Shao-Xian – sequence: 4 givenname: Hong-Tao surname: Hu fullname: Hu, Hong-Tao – sequence: 5 givenname: Cui-Yi surname: Zhang fullname: Zhang, Cui-Yi – sequence: 6 givenname: Shi-He surname: Guan fullname: Guan, Shi-He – sequence: 7 givenname: Yan-Li surname: Gu fullname: Gu, Yan-Li |
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Cites_doi | 10.1111/j.1440-1746.2004.03527.x 10.4049/jimmunol.173.10.6072 10.1016/j.jhep.2004.08.021 10.1111/j.1440-1746.2004.03360.x 10.1111/j.1365-2249.2004.02501.x 10.1189/jlb.0604372 10.1159/000069744 10.3904/kjim.1989.4.1.34 10.1146/annurev.immunol.19.1.65 10.1002/jmv.20016 10.1111/j.1440-1746.2004.03464.x 10.1097/00005176-200411000-00017 10.1054/drup.2001.0190 10.1046/j.1440-1746.2002.02767.x 10.1016/S1542-3565(04)00386-6 10.3748/wjg.v10.i11.1686 10.1111/j.1478-3231.2004.0889.x 10.1177/135965359800300404 10.1023/A:1026674705459 10.1111/j.1478-3231.2004.0982.x 10.1053/j.gastro.2004.08.055 10.1111/j.1365-2249.2005.02676.x 10.1093/intimm/8.4.569 10.1128/CDLI.9.6.1372-1375.2002 10.1023/A:1023366013858 10.1016/S1386-6532(00)00166-9 10.1016/S0021-9258(18)92765-1 10.1002/hep.20408 10.1084/jem.192.7.921 |
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Keywords | He Jie Tang Cytokines Chronic hepatitis B Lymphocyte subsets NK cell |
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Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 Telephone: +86-20-87334505 Fax: +86-20-87334505 Correspondence to: Dr. Shi-Jun Zhang, Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. zhsjun1967@hotmail.com Author contributions: All authors contributed equally to the work. |
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Snippet | To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B... AIMTo explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis... R5; AIM: To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic... AIM: To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic... |
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SubjectTerms | Adolescent Adult Antiviral Agents - therapeutic use Drugs, Chinese Herbal - therapeutic use Female Hepatitis B, Chronic - blood Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - immunology Humans Interleukin-8 - metabolism Killer Cells, Natural - metabolism Male Medicine, Chinese Traditional Middle Aged Pinellia Receptors, Interleukin-2 - metabolism T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - metabolism Treatment Outcome Tumor Necrosis Factor-alpha - metabolism Viral Hepatitis |
Title | He Jie Tang in the treatment of chronic hepatitis B patients |
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