ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration

• Published in: Developmental biology Vol. 327; no. 1; pp. 177 - 190
• Main Authors: Rojas-Muñoz, Agustin, Rajadhyksha, Shibani, Gilmour, Darren, van Bebber, Frauke, Antos, Christopher, Rodríguez Esteban, Concepción, Nüsslein-Volhard, Christiane, Izpisúa Belmonte, Juan Carlos
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2009
• Subjects: Amputation; Animals; Cell Movement; Cell Proliferation; ErbB2/ErbB3; Homeodomain Proteins - genetics; Neuregulin-1 - metabolism; Phosphatidylinositol 3-Kinases - metabolism; PI3K; Receptor, ErbB-2 - physiology; Receptor, ErbB-3 - physiology; Regeneration; Stem Cells - cytology; Stem Cells - physiology; Transcription Factors - genetics; Vertebrates; Zebrafish; Zebrafish Proteins - genetics; Regeneration; ErbB2/ErbB3; Zebrafish; PI3K

Epimorphic regeneration is a unique and complex instance of postembryonic growth observed in certain metazoans that is usually triggered by severe injury [Akimenko et al., 2003; Alvarado and Tsonis, 2006; Brockes, 1997; Endo et al., 2004]. Cell division and migration are two fundamental biological p...