Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation

• Published in: Cardiovascular research Vol. 119; no. 7; pp. 1606 - 1618
• Main Authors: Yamashiro, Yoshito, Ramirez, Karina, Nagayama, Kazuaki, Hattori, Naoko, Liu, Yu-Yu, Matsunaga, Shinji, Tomita, Shuhei, Kubota, Yoshiaki, Yanagisawa, Hiromi
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 04.07.2023
• Subjects: Animals; Carotid Arteries - surgery; Cells, Cultured; Endothelium; Epithelial-Mesenchymal Transition; Humans; Integrins; Leukocyte Common Antigens - metabolism; Mice; Neointima; Vascular Remodeling; Carotid artery ligation; Vascular wall remodelling; Hypoxia; Neointima; EndMT; CD45

Abstract Aims Endothelial-to-mesenchymal transition (EndMT) is a fundamental process in vascular remodelling. However, the precise regulatory mechanism of vascular remodelling during neointima formation and the source of neointima cells are not entirely understood. Methods and results To investigate...