The association between missing teeth and non‐alcoholic fatty liver disease in adults
Aims Long‐term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non‐alcoholic fatty liver disease (NAFLD). Tooth loss could reflect the accumulation of oral local inflammation, implying that number of missing teeth may associate wit...
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| Published in | Journal of clinical periodontology Vol. 45; no. 8; pp. 941 - 951 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.08.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Aims
Long‐term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non‐alcoholic fatty liver disease (NAFLD). Tooth loss could reflect the accumulation of oral local inflammation, implying that number of missing teeth may associate with NAFLD. This study evaluated the association between missing teeth and presence of NAFLD in a general population.
Materials and Methods
A cross‐sectional study of 24,470 adults was carried out from the Tianjin Chronic Low‐grade Systemic Inflammation and Health Cohort Study. The self‐reported number of missing teeth (excluding third molars) was recorded and classified into four categories: 0, 1–2, 3–5, and ≥6. The NAFLD was diagnosed by the liver ultrasonography. Associations were analysed by adjusted multivariable logistic regression.
Results
The multivariable‐adjusted odds ratios (95% confidence interval) of NAFLD across the categories of missing teeth were as follows: in males, 1.00 (reference), 1.04 (0.93–1.16), 1.06 (0.90–1.24), and 1.40 (1.09–1.81) (p for trend = 0.04); in females, 1.00 (reference), 0.98 (0.83–1.15), 1.11 (0.90–1.37), and 1.07 (0.77–1.48) (p for trend = 0.45).
Conclusions
The number of missing teeth was associated with a higher presence of NAFLD in males but not females. |
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| AbstractList | AimsLong‐term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non‐alcoholic fatty liver disease (NAFLD). Tooth loss could reflect the accumulation of oral local inflammation, implying that number of missing teeth may associate with NAFLD. This study evaluated the association between missing teeth and presence of NAFLD in a general population.Materials and MethodsA cross‐sectional study of 24,470 adults was carried out from the Tianjin Chronic Low‐grade Systemic Inflammation and Health Cohort Study. The self‐reported number of missing teeth (excluding third molars) was recorded and classified into four categories: 0, 1–2, 3–5, and ≥6. The NAFLD was diagnosed by the liver ultrasonography. Associations were analysed by adjusted multivariable logistic regression.ResultsThe multivariable‐adjusted odds ratios (95% confidence interval) of NAFLD across the categories of missing teeth were as follows: in males, 1.00 (reference), 1.04 (0.93–1.16), 1.06 (0.90–1.24), and 1.40 (1.09–1.81) (p for trend = 0.04); in females, 1.00 (reference), 0.98 (0.83–1.15), 1.11 (0.90–1.37), and 1.07 (0.77–1.48) (p for trend = 0.45).ConclusionsThe number of missing teeth was associated with a higher presence of NAFLD in males but not females. Long-term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non-alcoholic fatty liver disease (NAFLD). Tooth loss could reflect the accumulation of oral local inflammation, implying that number of missing teeth may associate with NAFLD. This study evaluated the association between missing teeth and presence of NAFLD in a general population. A cross-sectional study of 24,470 adults was carried out from the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study. The self-reported number of missing teeth (excluding third molars) was recorded and classified into four categories: 0, 1-2, 3-5, and ≥6. The NAFLD was diagnosed by the liver ultrasonography. Associations were analysed by adjusted multivariable logistic regression. The multivariable-adjusted odds ratios (95% confidence interval) of NAFLD across the categories of missing teeth were as follows: in males, 1.00 (reference), 1.04 (0.93-1.16), 1.06 (0.90-1.24), and 1.40 (1.09-1.81) (p for trend = 0.04); in females, 1.00 (reference), 0.98 (0.83-1.15), 1.11 (0.90-1.37), and 1.07 (0.77-1.48) (p for trend = 0.45). The number of missing teeth was associated with a higher presence of NAFLD in males but not females. Abstract Aims Long‐term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non‐alcoholic fatty liver disease ( NAFLD ). Tooth loss could reflect the accumulation of oral local inflammation, implying that number of missing teeth may associate with NAFLD . This study evaluated the association between missing teeth and presence of NAFLD in a general population. Materials and Methods A cross‐sectional study of 24,470 adults was carried out from the Tianjin Chronic Low‐grade Systemic Inflammation and Health Cohort Study. The self‐reported number of missing teeth (excluding third molars) was recorded and classified into four categories: 0, 1–2, 3–5, and ≥6. The NAFLD was diagnosed by the liver ultrasonography. Associations were analysed by adjusted multivariable logistic regression. Results The multivariable‐adjusted odds ratios (95% confidence interval) of NAFLD across the categories of missing teeth were as follows: in males, 1.00 (reference), 1.04 (0.93–1.16), 1.06 (0.90–1.24), and 1.40 (1.09–1.81) ( p for trend = 0.04); in females, 1.00 (reference), 0.98 (0.83–1.15), 1.11 (0.90–1.37), and 1.07 (0.77–1.48) ( p for trend = 0.45). Conclusions The number of missing teeth was associated with a higher presence of NAFLD in males but not females. Aims Long‐term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non‐alcoholic fatty liver disease (NAFLD). Tooth loss could reflect the accumulation of oral local inflammation, implying that number of missing teeth may associate with NAFLD. This study evaluated the association between missing teeth and presence of NAFLD in a general population. Materials and Methods A cross‐sectional study of 24,470 adults was carried out from the Tianjin Chronic Low‐grade Systemic Inflammation and Health Cohort Study. The self‐reported number of missing teeth (excluding third molars) was recorded and classified into four categories: 0, 1–2, 3–5, and ≥6. The NAFLD was diagnosed by the liver ultrasonography. Associations were analysed by adjusted multivariable logistic regression. Results The multivariable‐adjusted odds ratios (95% confidence interval) of NAFLD across the categories of missing teeth were as follows: in males, 1.00 (reference), 1.04 (0.93–1.16), 1.06 (0.90–1.24), and 1.40 (1.09–1.81) (p for trend = 0.04); in females, 1.00 (reference), 0.98 (0.83–1.15), 1.11 (0.90–1.37), and 1.07 (0.77–1.48) (p for trend = 0.45). Conclusions The number of missing teeth was associated with a higher presence of NAFLD in males but not females. |
| Author | Liu, Li Wu, Hongmei Xia, Yang Song, Kun Meng, Ge Wang, Xing Zhou, Ming Bao, Xue Shi, Hongbin Niu, Kaijun Sun, Shaomei Jia, Qiyu Fu, Kaiyu Gu, Yeqing Zhang, Qing Qiao, Feng |
| Author_xml | – sequence: 1 givenname: Feng surname: Qiao fullname: Qiao, Feng organization: Tianjin Medical University – sequence: 2 givenname: Kaiyu surname: Fu fullname: Fu, Kaiyu organization: Tianjin Medical University – sequence: 3 givenname: Qing surname: Zhang fullname: Zhang, Qing organization: Tianjin Medical University General Hospital – sequence: 4 givenname: Li surname: Liu fullname: Liu, Li organization: Tianjin Medical University General Hospital – sequence: 5 givenname: Ge surname: Meng fullname: Meng, Ge organization: Tianjin Medical University – sequence: 6 givenname: Hongmei surname: Wu fullname: Wu, Hongmei organization: Tianjin Medical University – sequence: 7 givenname: Yang surname: Xia fullname: Xia, Yang organization: Tianjin Medical University – sequence: 8 givenname: Xue surname: Bao fullname: Bao, Xue organization: Tianjin Medical University – sequence: 9 givenname: Yeqing surname: Gu fullname: Gu, Yeqing organization: Tianjin Medical University – sequence: 10 givenname: Hongbin surname: Shi fullname: Shi, Hongbin organization: Tianjin Medical University General Hospital – sequence: 11 givenname: Shaomei surname: Sun fullname: Sun, Shaomei organization: Tianjin Medical University General Hospital – sequence: 12 givenname: Xing surname: Wang fullname: Wang, Xing organization: Tianjin Medical University General Hospital – sequence: 13 givenname: Ming surname: Zhou fullname: Zhou, Ming organization: Tianjin Medical University General Hospital – sequence: 14 givenname: Qiyu surname: Jia fullname: Jia, Qiyu organization: Tianjin Medical University General Hospital – sequence: 15 givenname: Kun surname: Song fullname: Song, Kun organization: Tianjin Medical University General Hospital – sequence: 16 givenname: Kaijun orcidid: 0000-0002-8772-2481 surname: Niu fullname: Niu, Kaijun email: nkj0809@gmail.com, niukaijun@tmu.edu.cn organization: Tianjin Medical University General Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29779210$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s00784_018_2726_1 crossref_primary_10_1007_s40496_023_00342_3 crossref_primary_10_1038_s41522_024_00476_x crossref_primary_10_1139_cjpp_2021_0665 crossref_primary_10_1111_prd_12427 crossref_primary_10_3390_nu15051269 crossref_primary_10_1111_jcpe_13341 crossref_primary_10_3390_metabo12121212 crossref_primary_10_1007_s40496_021_00302_9 crossref_primary_10_1111_prd_12387 crossref_primary_10_1016_j_etap_2021_103755 crossref_primary_10_1016_j_heliyon_2024_e29340 crossref_primary_10_4254_wjh_v16_i5_688 crossref_primary_10_3390_ijms22073728 crossref_primary_10_1177_0022034519866442 |
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| Copyright | 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
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| Keywords | epidemiological non-alcoholic fatty liver disease population health missing teeth periodontal disease |
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| Notes | Funding information This study was supported by grants from the National Natural Science Foundation of China (No. 81673166, 81372118, 81372467 and 81302422), the Key Technologies R&D Program of Tianjin (Key Project: No. 11ZCGYSY05700, 12ZCZDSY20400, 13ZCZDSY20200, and 15YFYZSY00020), the National Science and Technology Support Program (No. 2012BAI02B02), 2012 and 2016 Chinese Nutrition Society (CNS) Nutrition Research Foundation—DSM Research Fund (No. 2014‐071 and 2016‐046), the Technologies Development Program of Beichen District of Tianjin (No. bcws2013‐21 and bcws2014‐05), the Technologies Project of Tianjin Binhai New Area (No. 2013‐02‐04 and 2013‐02‐06), the Science Foundation of Tianjin Medical University (No. 2010KY28 and 2013KYQ24), the Key Laboratory of Public Health Safety (Fudan University), Ministry of Education (No. GW2014‐5), and the National Training Programs of Innovation and Entrepreneurship for Undergraduates (No. 201510062013), China. The Science and Technology Development Fund of Tianjin Education Commission for Higher Education (Grant No: 20140135). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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Long‐term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non‐alcoholic fatty liver... Long-term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non-alcoholic fatty liver... Abstract Aims Long‐term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non‐alcoholic... AimsLong‐term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non‐alcoholic fatty liver... AIMSLong-term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non-alcoholic fatty liver... |
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| SubjectTerms | Dentistry epidemiological Fatty liver Gum disease Health risk assessment Inflammation Liver diseases missing teeth Molars non‐alcoholic fatty liver disease periodontal disease population health Teeth Ultrasound |
| Title | The association between missing teeth and non‐alcoholic fatty liver disease in adults |
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