Post‐prandial reflux suppression by a raft‐forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH‐impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, double‐blind study in reflux patients

• Published in: Alimentary pharmacology & therapeutics Vol. 37; no. 11; pp. 1093 - 1102
• Main Authors: Sweis, R., Kaufman, E., Anggiansah, A., Wong, T., Dettmar, P., Fried, M., Schwizer, W., Avvari, R. K., Pal, A., Fox, M.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.06.2013
• Subjects: Adult; Aged; Alginates - therapeutic use; Aluminum Hydroxide - therapeutic use; Antacids - therapeutic use; Biological and medical sciences; Cross-Over Studies; Digestive system; Double-Blind Method; Drug Combinations; Electric Impedance; Esophageal pH Monitoring; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gastroesophageal Reflux - diagnosis; Gastroesophageal Reflux - drug therapy; Humans; Hydrogen-Ion Concentration; Magnesium Oxide - therapeutic use; Magnetic Resonance Imaging; Male; Manometry; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Postprandial Period; Silicic Acid - therapeutic use; Sodium Bicarbonate - therapeutic use; Treatment Outcome; Human; Evaluation; Healthy subject; Alginates; Document; Nuclear magnetic resonance imaging; Randomization; Surveillance; Double blind study; pH; Medical imagery; Impedance; Antiacid; Comparative study

Summary Background Alginates form a raft above the gastric contents, which may suppress gastro‐oesophageal reflux; however, inconsistent effects have been reported in mechanistic and clinical studies. Aims To visualise reflux suppression by an alginate–antacid [Gaviscon Advance (GA), Reckitt Benckis...