Identification of active constraints in dynamic flux balance analysis

• Published in: Biotechnology progress Vol. 33; no. 1; pp. 26 - 36
• Main Authors: Nikdel, Ali, Budman, Hector
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2017
• Subjects: Algorithms; Bordetella pertussis; Computer Simulation; constraints; dynamic flux balance model; E coli; Escherichia coli - genetics; Escherichia coli - metabolism; Metabolic Networks and Pathways - genetics; Models, Biological; Sensitivity analysis; Systems Biology; dynamic flux balance model; Bordetella pertussis; constraints; E. coli

This study deals with the calibration of dynamic metabolic flux models that are formulated as the maximization of an objective subject to constraints. Two approaches were applied for identifying the constraints from data. In the first approach a minimal active number of limiting constraints is found...