Use of a combination formulation of bismuth, metronidazole and tetracycline with omeprazole as a rescue therapy for eradication of Helicobacter pylori

• Published in: Alimentary pharmacology & therapeutics Vol. 40; no. 2; pp. 171 - 177
• Main Authors: Delchier, J. C., Malfertheiner, P., Thieroff‐Ekerdt, R.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.07.2014
• Subjects: Adult; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Anti-Ulcer Agents - administration & dosage; Anti-Ulcer Agents - adverse effects; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Breath Tests; Drug Combinations; Drug Resistance, Bacterial; Drug Therapy, Combination; Female; Helicobacter Infections - diagnosis; Helicobacter Infections - drug therapy; Helicobacter Infections - metabolism; Helicobacter pylori; Human bacterial diseases; Humans; Infectious diseases; Male; Medical sciences; Metronidazole - administration & dosage; Metronidazole - adverse effects; Middle Aged; Omeprazole - administration & dosage; Omeprazole - adverse effects; Organometallic Compounds - administration & dosage; Organometallic Compounds - adverse effects; Tetracycline - administration & dosage; Tetracycline - adverse effects; Treatment Outcome; Urea - metabolism; Young Adult; Nitro compound; Imidazole derivatives; H; Spirillaceae; Antiulcer agent; K; Eradication; Proton pump inhibitor; Antiprotozoal agent; Antifungal agent; Helicobacter pylori; Antisecretory agent; Formulation; Bacteria; Protein synthesis inhibitor; Spirillales; Enzyme; Tetracycline derivatives; Enzyme inhibitor; Tetracycline; Infection; Omeprazole; Antibiotic; Benzimidazole derivatives; Bacteriosis; exchanging ATPase; Hydrolases; Parasiticide; Metronidazole; Salvage treatment; Antibacterial agent

Summary Background Helicobacter pylori infection occurs in children and adults worldwide. Standard triple therapy of omeprazole, amoxicillin and clarithromycin (OAC) may not be optimal. Aim To evaluate quadruple therapy with bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride,...