Haematopoietic stem cell transplantation for severe sickle cell disease in childhood: a single centre experience of 50 patients

• Published in: British journal of haematology Vol. 165; no. 3; pp. 402 - 408
• Main Authors: Dedeken, Laurence, Lê, Phu Q., Azzi, Nadira, Brachet, Cécile, Heijmans, Catherine, Huybrechts, Sophie, Devalck, Christine, Rozen, Laurence, Ngalula, Malou, Ferster, Alina
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.05.2014
• Subjects: Adolescent; Anemia, Sickle Cell - surgery; Anemias. Hemoglobinopathies; Animals; Biological and medical sciences; Child; Child, Preschool; Diseases of red blood cells; Female; Genotype; haematopoietic stem cell transplant; Hematologic and hematopoietic diseases; Hematopoietic Stem Cell Transplantation - methods; Humans; hydroxycarbamide; Infant; Male; Medical sciences; Rabbits; sickle cell disease; Survival Analysis; Transplantation Conditioning - methods; Transplantation, Autologous; Tumors; Human; Antineoplastic agent; Hemoglobinopathy; Sickle cell anemia; Hydroxycarbamide; Hematology; Stem cell; Hematopoietic cell; Hemopathy; Genetic disease; sickle cell disease; Hemolytic anemia; Cancerology; Antimetabolic; haematopoietic stem cell transplant; Child; Hematopoietic stem cell transplantation; hydroxycarbamide

Summary Despite improvements in medical management, sickle cell disease (SCD) remains associated with severe morbidity and decreased survival. Allogeneic haematopoietic stem cell transplantation (HSCT) remains the only curative approach. We report the outcome of 50 consecutive children with severe S...