LY303511 displays antiproliferation potential against oral cancer cells in vitro and in vivo

LY303511 was developed as a negative control of LY294002 without pan‐phosphoinositide 3‐kinase (PI3K) inhibition. We hypothesize LY303511 generate reactive oxygen species (ROS) to induce apoptosis for killing oral cancer cells. In MTS assay, LY303511 dose‐responsively decreases survival in three kin...

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Published in	Environmental toxicology Vol. 34; no. 8; pp. 958 - 967
Main Authors	Tang, Jen‐Yang, Xu, Yi‐Hua, Lin, Li‐Ching, Ou‐Yang, Fu, Wu, Kuang‐Han, Tsao, Li‐Yi, Yu, Tzu‐Jung, Huang, Hurng‐Wern, Wang, Hui‐Ru, Liu, Wangta, Chang, Hsueh‐Wei
Format	Journal Article
Language	English
Published	Hoboken, USA John Wiley & Sons, Inc 01.08.2019 Wiley Subscription Services, Inc
Subjects	1-Phosphatidylinositol 3-kinase 8-Hydroxydeoxyguanosine Annexin V Apoptosis Assaying Cancer Cells Danio rerio Displays DNA DNA damage Freshwater fishes Health risk assessment Kinases LY303511 Mitochondria mouth neoplasms neoplasm cells Neoplasms Oral cancer Oxidative stress phosphatidylinositol 3-kinase preferential killing Reactive oxygen species Superoxide Survival Xenografts Zebrafish zebrafish xenograft model LY303511 preferential killing oral cancer oxidative stress zebrafish xenograft model
Online Access	Get full text
ISSN	1520-4081 1522-7278 1522-7278
DOI	10.1002/tox.22767

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Abstract	LY303511 was developed as a negative control of LY294002 without pan‐phosphoinositide 3‐kinase (PI3K) inhibition. We hypothesize LY303511 generate reactive oxygen species (ROS) to induce apoptosis for killing oral cancer cells. In MTS assay, LY303511 dose‐responsively decreases survival in three kinds of oral cancer cells but little damage to normal oral cells (HGF‐1). Two oral cancer cells (CAL 27 and SCC‐9) with highly sensitivity to LY303511 were used. In 7‐aminoactinomycin D (7AAD) assay, LY303511 slightly increases subG1 population in oral cancer cells. In annexin V/7AAD and/or pancaspase assays, LY303511 induces apoptosis in oral cancer cells but HGF‐1 cells remains in basal level. In oxidative stress, LY303511 induces ROS and mitochondrial superoxide in oral cancer cells. In 8‐oxo‐2'‐deoxyguanosine assay, LY303511 induces oxidative DNA damage in oral cancer cells. In zebrafish model, LY303511 inhibits CAL 27‐xenografted tumor growth. Therefore, LY303511 displays antiproliferation potential against oral cancer cells in vitro and in vivo.
AbstractList	LY303511 was developed as a negative control of LY294002 without pan‐phosphoinositide 3‐kinase (PI3K) inhibition. We hypothesize LY303511 generate reactive oxygen species (ROS) to induce apoptosis for killing oral cancer cells. In MTS assay, LY303511 dose‐responsively decreases survival in three kinds of oral cancer cells but little damage to normal oral cells (HGF‐1). Two oral cancer cells (CAL 27 and SCC‐9) with highly sensitivity to LY303511 were used. In 7‐aminoactinomycin D (7AAD) assay, LY303511 slightly increases subG1 population in oral cancer cells. In annexin V/7AAD and/or pancaspase assays, LY303511 induces apoptosis in oral cancer cells but HGF‐1 cells remains in basal level. In oxidative stress, LY303511 induces ROS and mitochondrial superoxide in oral cancer cells. In 8‐oxo‐2'‐deoxyguanosine assay, LY303511 induces oxidative DNA damage in oral cancer cells. In zebrafish model, LY303511 inhibits CAL 27‐xenografted tumor growth. Therefore, LY303511 displays antiproliferation potential against oral cancer cells in vitro and in vivo. LY303511 was developed as a negative control of LY294002 without pan‐phosphoinositide 3‐kinase (PI3K) inhibition. We hypothesize LY303511 generate reactive oxygen species (ROS) to induce apoptosis for killing oral cancer cells. In MTS assay, LY303511 dose‐responsively decreases survival in three kinds of oral cancer cells but little damage to normal oral cells (HGF‐1). Two oral cancer cells (CAL 27 and SCC‐9) with highly sensitivity to LY303511 were used. In 7‐aminoactinomycin D (7AAD) assay, LY303511 slightly increases subG1 population in oral cancer cells. In annexin V/7AAD and/or pancaspase assays, LY303511 induces apoptosis in oral cancer cells but HGF‐1 cells remains in basal level. In oxidative stress, LY303511 induces ROS and mitochondrial superoxide in oral cancer cells. In 8‐oxo‐2'‐deoxyguanosine assay, LY303511 induces oxidative DNA damage in oral cancer cells. In zebrafish model, LY303511 inhibits CAL 27‐xenografted tumor growth. Therefore, LY303511 displays antiproliferation potential against oral cancer cells in vitro and in vivo . LY303511 was developed as a negative control of LY294002 without pan-phosphoinositide 3-kinase (PI3K) inhibition. We hypothesize LY303511 generate reactive oxygen species (ROS) to induce apoptosis for killing oral cancer cells. In MTS assay, LY303511 dose-responsively decreases survival in three kinds of oral cancer cells but little damage to normal oral cells (HGF-1). Two oral cancer cells (CAL 27 and SCC-9) with highly sensitivity to LY303511 were used. In 7-aminoactinomycin D (7AAD) assay, LY303511 slightly increases subG1 population in oral cancer cells. In annexin V/7AAD and/or pancaspase assays, LY303511 induces apoptosis in oral cancer cells but HGF-1 cells remains in basal level. In oxidative stress, LY303511 induces ROS and mitochondrial superoxide in oral cancer cells. In 8-oxo-2'-deoxyguanosine assay, LY303511 induces oxidative DNA damage in oral cancer cells. In zebrafish model, LY303511 inhibits CAL 27-xenografted tumor growth. Therefore, LY303511 displays antiproliferation potential against oral cancer cells in vitro and in vivo.LY303511 was developed as a negative control of LY294002 without pan-phosphoinositide 3-kinase (PI3K) inhibition. We hypothesize LY303511 generate reactive oxygen species (ROS) to induce apoptosis for killing oral cancer cells. In MTS assay, LY303511 dose-responsively decreases survival in three kinds of oral cancer cells but little damage to normal oral cells (HGF-1). Two oral cancer cells (CAL 27 and SCC-9) with highly sensitivity to LY303511 were used. In 7-aminoactinomycin D (7AAD) assay, LY303511 slightly increases subG1 population in oral cancer cells. In annexin V/7AAD and/or pancaspase assays, LY303511 induces apoptosis in oral cancer cells but HGF-1 cells remains in basal level. In oxidative stress, LY303511 induces ROS and mitochondrial superoxide in oral cancer cells. In 8-oxo-2'-deoxyguanosine assay, LY303511 induces oxidative DNA damage in oral cancer cells. In zebrafish model, LY303511 inhibits CAL 27-xenografted tumor growth. Therefore, LY303511 displays antiproliferation potential against oral cancer cells in vitro and in vivo.
Author	Lin, Li‐Ching Wang, Hui‐Ru Tang, Jen‐Yang Wu, Kuang‐Han Yu, Tzu‐Jung Liu, Wangta Ou‐Yang, Fu Huang, Hurng‐Wern Chang, Hsueh‐Wei Xu, Yi‐Hua Tsao, Li‐Yi
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CitedBy_id	crossref_primary_10_1016_j_intimp_2023_109997 crossref_primary_10_3390_ijms241512079 crossref_primary_10_3390_cancers13102450 crossref_primary_10_3389_fmed_2022_875517 crossref_primary_10_3390_antiox9111120 crossref_primary_10_3390_antiox9090876
Cites_doi	10.1186/1756-9966-29-34 10.2741/s465 10.1016/j.fct.2013.07.012 10.1016/j.archoralbio.2016.02.019 10.1016/S0014-5793(04)00058-4 10.2147/OTT.S138123 10.1002/tox.22625 10.1016/S0021-9258(17)37680-9 10.1016/j.semcdb.2017.05.023 10.1124/jpet.105.083550 10.1002/tox.22516 10.1016/j.cell.2017.07.029 10.1016/j.ctrv.2017.07.005 10.1158/0008-5472.CAN-05-0152 10.1089/dna.2015.3044 10.3390/molecules23040849 10.1016/j.bbrc.2008.09.094 10.1016/j.bcp.2012.08.028 10.3390/molecules170910916 10.1016/j.bcp.2011.09.025 10.1002/tox.22588 10.1016/j.advenzreg.2008.04.002 10.1016/j.bbrc.2007.04.106 10.3389/fphys.2017.00634 10.1111/fcp.12043 10.1177/00220345940730080301 10.1158/0008-5472.CAN-08-1996 10.1371/journal.pone.0068425 10.1155/2015/294303 10.1021/jf103488j 10.1002/tox.22629 10.1038/sj.cdd.4402177 10.1074/jbc.270.19.11684 10.1016/j.freeradbiomed.2009.12.022 10.1016/j.ceb.2017.02.007 10.1002/j.1460-2075.1996.tb00911.x 10.18632/oncotarget.5414 10.1016/j.ctrv.2008.07.004 10.1038/nrd2803
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Notes	Funding information Health and Welfare Surcharge of Tobacco Products, the Ministry of Health and Welfare, Taiwan, Republic of China, Grant/Award Number: MOHW108‐TDU‐B‐212‐124016; Kaohsiung Medical University Hospital, Grant/Award Numbers: KMUH105‐5M24, KMUH107‐7R74; Ministry of Science and Technology, Taiwan, Grant/Award Numbers: MOST 107‐2314‐B‐037‐048, MOST 107‐2314‐B‐037‐057, MOST 107‐2320‐B‐037‐016, MOST 107‐2628‐B‐037‐001, MOST107‐2311‐B‐037‐001; National Sun Yat‐sen University‐KMU Joint Research Project, Grant/Award Numbers: #NSYSUKMU 108‐P001, NSYSUKMU 108‐P001; Ministry of Health and Welfare, Taiwan, Republic of China; Health and Welfare Surcharge of Tobacco Products; ChangHua Christian Hospital‐KMU Fund, Grant/Award Number: 108‐CCH‐KMU‐008; Kaohsiung Medical University; Ministry of Science and Technology ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
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References	2012; 83 2009; 69 2017; 8 2015; 6 2000; 6 2005; 314 2017; 45 2017; 170 2018; 80 2005; 65 2012; 17 2011; 59 2014; 28 2018; 23 2013; 8 1996; 15 1995; 270 2007; 14 2016; 35 2009; 35 2013; 59 2010; 48 2007; 358 1994; 269 2017; 59 2010; 29 2017; 10 2015; 2015 2008; 48 2009; 8 2008; 377 2004; 559 2018; 33 2016; 8 1994; 73 2012; 84 2016; 66 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_26_1 e_1_2_7_27_1 e_1_2_7_28_1 e_1_2_7_29_1 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_37_1 e_1_2_7_38_1 e_1_2_7_39_1 Hu L (e_1_2_7_2_1) 2000; 6
References_xml	– volume: 377 start-page: 187 issue: 1 year: 2008 end-page: 190 article-title: LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3‐kinase‐Akt pathway publication-title: Biochem Biophys Res Commun – volume: 59 start-page: 2284 issue: 6 year: 2011 end-page: 2290 article-title: (−)‐Anonaine induces DNA damage and inhibits growth and migration of human lung carcinoma h1299 cells publication-title: J Agric Food Chem – volume: 48 start-page: 179 year: 2008 end-page: 187 article-title: Protein kinase CK2‐‐a key suppressor of apoptosis publication-title: Adv Enzyme Regul – volume: 80 start-page: 50 year: 2018 end-page: 64 article-title: ROS signalling in the biology of cancer publication-title: Semin Cell Dev Biol – volume: 8 start-page: 579 issue: 7 year: 2009 end-page: 591 article-title: Targeting cancer cells by ROS‐mediated mechanisms: a radical therapeutic approach? publication-title: Nat Rev Drug Discov – volume: 48 start-page: 749 issue: 6 year: 2010 end-page: 762 article-title: Reactive oxygen species, cellular redox systems, and apoptosis publication-title: Free Radic Biol Med – volume: 59 start-page: 657 year: 2013 end-page: 669 article-title: Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme publication-title: Food Chem Toxicol – volume: 14 start-page: 1813 issue: 10 year: 2007 end-page: 1825 article-title: LY303511 amplifies TRAIL‐induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization publication-title: Cell Death Differ – volume: 17 start-page: 10916 issue: 9 year: 2012 end-page: 10927 article-title: Antiproliferation and induction of apoptosis in Ca9‐22 oral cancer cells by ethanolic extract of publication-title: Molecules – volume: 35 start-page: 210 issue: 5 year: 2016 end-page: 216 article-title: Butanol‐partitioned extraction from aqueous extract of inhibits cell proliferation of oral cancer cells involving apoptosis and oxidative stress publication-title: DNA Cell Biol – volume: 6 start-page: 34859 issue: 33 year: 2015 end-page: 34874 article-title: Targeting EMP3 suppresses proliferation and invasion of hepatocellular carcinoma cells through inactivation of PI3K/Akt pathway publication-title: Oncotarget – volume: 559 start-page: 141 issue: 1–3 year: 2004 end-page: 144 article-title: LY294002 inhibits monocyte chemoattractant protein‐1 expression through a phosphatidylinositol 3‐kinase‐independent mechanism publication-title: FEBS Lett – volume: 314 start-page: 1134 issue: 3 year: 2005 end-page: 1143 article-title: LY303511 (2‐piperazinyl‐8‐phenyl‐4H‐1‐benzopyran‐4‐one) acts via phosphatidylinositol 3‐kinase‐independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)‐ and non‐mTOR‐dependent mechanisms publication-title: J Pharmacol Exp Ther – volume: 65 start-page: 6264 issue: 14 year: 2005 end-page: 6274 article-title: LY294002 and LY303511 sensitize tumor cells to drug‐induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3‐kinase‐Akt pathway publication-title: Cancer Res – volume: 8 issue: 7 year: 2013 article-title: Flow cytometric quantification of all phases of the cell cycle and apoptosis in a two‐color fluorescence plot publication-title: PLoS One – volume: 358 start-page: 203 issue: 1 year: 2007 end-page: 208 article-title: Simple quantitative detection of mitochondrial superoxide production in live cells publication-title: Biochem Biophys Res Commun – volume: 45 start-page: 62 year: 2017 end-page: 71 article-title: PI3K signaling in cancer: beyond AKT publication-title: Curr Opin Cell Biol – volume: 29 start-page: 34 year: 2010 article-title: Phosphatidylinositol 3‐kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo publication-title: J Exp Clin Cancer Res – volume: 10 start-page: 3289 year: 2017 end-page: 3297 article-title: Reactive oxygen species mediate soft corals‐derived sinuleptolide‐induced antiproliferation and DNA damage in oral cancer cells publication-title: Onco Targets Ther – volume: 35 start-page: 32 issue: 1 year: 2009 end-page: 46 article-title: Elevated copper and oxidative stress in cancer cells as a target for cancer treatment publication-title: Cancer Treat Rev – volume: 69 start-page: 1941 issue: 5 year: 2009 end-page: 1950 article-title: LY303511 enhances TRAIL sensitivity of SHEP‐1 neuroblastoma cells via hydrogen peroxide‐mediated mitogen‐activated protein kinase activation and up‐regulation of death receptors publication-title: Cancer Res – volume: 73 start-page: 1407 issue: 8 year: 1994 end-page: 1415 article-title: Regulation of PG synthase by EGF and PDGF in human oral, breast, stomach, and fibrosarcoma cancer cell lines publication-title: J Dent Res – volume: 33 start-page: 1029 issue: 10 year: 2018 end-page: 1038 article-title: CYP450‐mediated mitochondrial ROS production involved in arecoline N‐oxide‐induced oxidative damage in liver cell lines publication-title: Environ Toxicol – volume: 33 start-page: 1229 year: 2018 end-page: 1236 article-title: Chemical evaluation and cytotoxic mechanism investigation of extract in lymphoma SUP‐T1 cells publication-title: Environ Toxicol – volume: 6 start-page: 880 issue: 3 year: 2000 end-page: 886 article-title: In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3‐kinase inhibitor (LY294002) publication-title: Clin Cancer Res – volume: 28 start-page: 414 issue: 4 year: 2014 end-page: 422 article-title: Phosphatidylinositol 3‐kinases inhibitor LY294002 potentiates the cytotoxic effects of doxorubicin, vincristine, and etoposide in a panel of cancer cell lines publication-title: Fundam Clin Pharmacol – volume: 33 start-page: 295 issue: 3 year: 2018 end-page: 304 article-title: 4beta‐Hydroxywithanolide E selectively induces oxidative DNA damage for selective killing of oral cancer cells publication-title: Environ Toxicol – volume: 23 start-page: 849 issue: 4 year: 2018 article-title: Sinularin selectively kills breast cancer cells showing G2/M arrest, apoptosis, and oxidative DNA damage publication-title: Molecules – volume: 170 start-page: 605 issue: 4 year: 2017 end-page: 635 article-title: The PI3K pathway in human disease publication-title: Cell – volume: 59 start-page: 93 year: 2017 end-page: 101 article-title: Phosphoinositide 3‐kinase (PI3K) pathway inhibitors in solid tumors: from laboratory to patients publication-title: Cancer Treat Rev – volume: 15 start-page: 5256 issue: 19 year: 1996 end-page: 5267 article-title: Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002 publication-title: EMBO J – volume: 84 start-page: 1307 issue: 10 year: 2012 end-page: 1317 article-title: Reactive oxygen species (ROS) and sensitization to TRAIL‐induced apoptosis, in Bayesian network modelling of HeLa cell response to LY303511 publication-title: Biochem Pharmacol – volume: 270 start-page: 11684 issue: 19 year: 1995 end-page: 11691 article-title: Antagonists of phosphatidylinositol 3‐kinase block activation of several novel protein kinases in neutrophils publication-title: J Biol Chem – volume: 8 start-page: 312 year: 2016 end-page: 320 article-title: Role of mitochondria, ROS, and DNA damage in arsenic induced carcinogenesis publication-title: Front Biosci – volume: 2015 start-page: 294303 year: 2015 article-title: Increased oxidative stress as a selective anticancer therapy publication-title: Oxid Med Cell Longev – volume: 83 start-page: 106 issue: 1 year: 2012 end-page: 114 article-title: The phosphatidylinositol 3‐kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappaB inhibition, in a PI3K‐independent mechanism publication-title: Biochem Pharmacol – volume: 66 start-page: 147 year: 2016 end-page: 154 article-title: Sinuleptolide inhibits proliferation of oral cancer Ca9‐22 cells involving apoptosis, oxidative stress, and DNA damage publication-title: Arch Oral Biol – volume: 269 start-page: 5241 issue: 7 year: 1994 end-page: 5248 article-title: A specific inhibitor of phosphatidylinositol 3‐kinase, 2‐(4‐morpholinyl)‐8‐phenyl‐4H‐1‐benzopyran‐4‐one (LY294002) publication-title: J Biol Chem – volume: 8 start-page: 634 year: 2017 article-title: Withaferin A induces oxidative stress‐mediated apoptosis and DNA damage in oral cancer cells publication-title: Front Physiol – volume: 33 start-page: 1195 issue: 11 year: 2018 end-page: 1203 article-title: A novel sulfonyl chromen‐4‐ones (CHW09) preferentially kills oral cancer cells showing apoptosis, oxidative stress, and DNA damage publication-title: Environ Toxicol – ident: e_1_2_7_10_1 doi: 10.1186/1756-9966-29-34 – volume: 6 start-page: 880 issue: 3 year: 2000 ident: e_1_2_7_2_1 article-title: In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3‐kinase inhibitor (LY294002) publication-title: Clin Cancer Res – ident: e_1_2_7_35_1 doi: 10.2741/s465 – ident: e_1_2_7_40_1 doi: 10.1016/j.fct.2013.07.012 – ident: e_1_2_7_20_1 doi: 10.1016/j.archoralbio.2016.02.019 – ident: e_1_2_7_11_1 doi: 10.1016/S0014-5793(04)00058-4 – ident: e_1_2_7_28_1 doi: 10.2147/OTT.S138123 – ident: e_1_2_7_37_1 doi: 10.1002/tox.22625 – ident: e_1_2_7_8_1 doi: 10.1016/S0021-9258(17)37680-9 – ident: e_1_2_7_18_1 doi: 10.1016/j.semcdb.2017.05.023 – ident: e_1_2_7_12_1 doi: 10.1124/jpet.105.083550 – ident: e_1_2_7_29_1 doi: 10.1002/tox.22516 – ident: e_1_2_7_5_1 doi: 10.1016/j.cell.2017.07.029 – ident: e_1_2_7_6_1 doi: 10.1016/j.ctrv.2017.07.005 – ident: e_1_2_7_14_1 doi: 10.1158/0008-5472.CAN-05-0152 – ident: e_1_2_7_38_1 doi: 10.1089/dna.2015.3044 – ident: e_1_2_7_23_1 doi: 10.3390/molecules23040849 – ident: e_1_2_7_32_1 doi: 10.1016/j.bbrc.2008.09.094 – ident: e_1_2_7_15_1 doi: 10.1016/j.bcp.2012.08.028 – ident: e_1_2_7_21_1 doi: 10.3390/molecules170910916 – ident: e_1_2_7_34_1 doi: 10.1016/j.bcp.2011.09.025 – ident: e_1_2_7_25_1 doi: 10.1002/tox.22588 – ident: e_1_2_7_41_1 doi: 10.1016/j.advenzreg.2008.04.002 – ident: e_1_2_7_27_1 doi: 10.1016/j.bbrc.2007.04.106 – ident: e_1_2_7_24_1 doi: 10.3389/fphys.2017.00634 – ident: e_1_2_7_9_1 doi: 10.1111/fcp.12043 – ident: e_1_2_7_19_1 doi: 10.1177/00220345940730080301 – ident: e_1_2_7_13_1 doi: 10.1158/0008-5472.CAN-08-1996 – ident: e_1_2_7_22_1 doi: 10.1371/journal.pone.0068425 – ident: e_1_2_7_16_1 doi: 10.1155/2015/294303 – ident: e_1_2_7_39_1 doi: 10.1021/jf103488j – ident: e_1_2_7_26_1 doi: 10.1002/tox.22629 – ident: e_1_2_7_31_1 doi: 10.1038/sj.cdd.4402177 – ident: e_1_2_7_30_1 doi: 10.1074/jbc.270.19.11684 – ident: e_1_2_7_36_1 doi: 10.1016/j.freeradbiomed.2009.12.022 – ident: e_1_2_7_4_1 doi: 10.1016/j.ceb.2017.02.007 – ident: e_1_2_7_7_1 doi: 10.1002/j.1460-2075.1996.tb00911.x – ident: e_1_2_7_3_1 doi: 10.18632/oncotarget.5414 – ident: e_1_2_7_17_1 doi: 10.1016/j.ctrv.2008.07.004 – ident: e_1_2_7_33_1 doi: 10.1038/nrd2803
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Snippet	LY303511 was developed as a negative control of LY294002 without pan‐phosphoinositide 3‐kinase (PI3K) inhibition. We hypothesize LY303511 generate reactive... LY303511 was developed as a negative control of LY294002 without pan-phosphoinositide 3-kinase (PI3K) inhibition. We hypothesize LY303511 generate reactive...
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SubjectTerms	1-Phosphatidylinositol 3-kinase 8-Hydroxydeoxyguanosine Annexin V Apoptosis Assaying Cancer Cells Danio rerio Displays DNA DNA damage Freshwater fishes Health risk assessment Kinases LY303511 Mitochondria mouth neoplasms neoplasm cells Neoplasms Oral cancer Oxidative stress phosphatidylinositol 3-kinase preferential killing Reactive oxygen species Superoxide Survival Xenografts Zebrafish zebrafish xenograft model
Title	LY303511 displays antiproliferation potential against oral cancer cells in vitro and in vivo
URI	https://onlinelibrary.wiley.com/doi/abs/10.1002%2Ftox.22767 https://www.ncbi.nlm.nih.gov/pubmed/31115172 https://www.proquest.com/docview/2252253226 https://www.proquest.com/docview/2232089448 https://www.proquest.com/docview/2286885833
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