Changing perspectives on how the permeation pathway through potassium channels is regulated

• Published in: The Journal of physiology Vol. 599; no. 7; pp. 1961 - 1976
• Main Authors: Black, Katrina A., Jin, Ruitao, He, Sitong, Gulbis, Jacqueline M.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2021
• Subjects: cryo‐EM; crystal structure; molecular dynamics; non‐canonical gating; permeation gating; Potassium; Potassium - metabolism; potassium channel; Potassium channels; Potassium Channels - metabolism; Protein Conformation; selectivity filter; permeation gating; selectivity filter; crystal structure; non-canonical gating; potassium channel; molecular dynamics; cryo-EM

The primary means by which ion permeation through potassium channels is controlled, and the key to selective intervention in a range of pathophysiological conditions, is the process by which channels switch between non‐conducting and conducting states. Conventionally, this has been explained by a st...