Sinularin induces oxidative stress‐mediated G2/M arrest and apoptosis in oral cancer cells

• Published in: Environmental toxicology Vol. 32; no. 9; pp. 2124 - 2132
• Main Authors: Chang, Yung‐Ting, Wu, Chang‐Yi, Tang, Jen‐Yang, Huang, Chiung‐Yao, Liaw, Chih‐Chuang, Wu, Shih‐Hsiung, Sheu, Jyh‐Horng, Chang, Hsueh‐Wei
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2017
• Subjects: Acetylcysteine; Acetylcysteine - pharmacology; Adenosine diphosphate; ADP; Annexin V; Antineoplastic Agents - pharmacology; Antineoplastic Agents - toxicity; Antioxidants; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; Cancer; caspases; Caspases - metabolism; Cdc2 protein; Cell cycle; Cell Line, Tumor; Cell morphology; Cell Survival - drug effects; cell viability; Cells; Corals; Cyclin B1; cyclins; Cytology; Cytometry; Diterpenes - pharmacology; Diterpenes - toxicity; drugs; Flow cytometry; G2 Phase Cell Cycle Checkpoints - drug effects; G2/M arrest; Heterocyclic Compounds, 3-Ring - pharmacology; Heterocyclic Compounds, 3-Ring - toxicity; Humans; mouth neoplasms; Mouth Neoplasms - drug therapy; NAD ADP-ribosyltransferase; neoplasm cells; Oral cancer; Oxidative stress; Oxidative Stress - drug effects; Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerases - metabolism; Pretreatment; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Regulatory proteins; Ribose; sinularin; soft coral; therapeutics; Western blotting; sinularin; apoptosis; soft coral; G2/M arrest; oxidative stress

Soft corals‐derived natural product, sinularin, was antiproliferative against some cancers but its effect and detailed mechanism on oral cancer cells remain unclear. The subject of this study is to examine the antioral cancer effects and underlying detailed mechanisms in terms of cell viability, oxi...