(+)-Flavipucine, the Missing Member of the Pyridione Epoxide Family of Fungal Antibiotics

• Published in: European Journal of Organic Chemistry Vol. 2011; no. 26; pp. 5156 - 5162
• Main Authors: Loesgen, Sandra, Bruhn, Torsten, Meindl, Kathrin, Dix, Ina, Schulz, Barbara, Zeeck, Axel, Bringmann, Gerhard
• Format: Book Review Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.09.2011; WILEY‐VCH Verlag; Wiley; Wiley-VCH
• Subjects: Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Biological and medical sciences; Chemistry; Chemistry, Organic; Exact sciences and technology; Flavipucine; Fungal metabolites; General aspects; Heterocyclic compounds; Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives; Medical sciences; Natural products; Organic chemistry; Pharmacology. Drug treatments; Physical Sciences; Preparations and properties; Science & Technology; GEOMETRIES; Antifungal agents; MACROPHOMA FRUIT ROT; HARTREE-FOCK; PERTURBATION-THEORY; Antibiotics; Natural products; Fungal metabolites; Flavipucine; BASIS-SETS; ENERGIES; EFFICIENT; MOLECULAR-FORCE FIELD; Antibiotic; Antifungal agent; Metabolite; Epoxide; Natural compound; Oxygen heterocycle

From the culture extracts of the endophytic fungus, Phoma sp., isolated from the plant Salsola oppositifolia, five secondary metabolites were isolated and characterized. On biomalt agar medium, the strain produced the known substances chrysophanol (1) and hypothemycin (2), while from liquid‐surface...